NATIONAL BIOMEDICAL COMPUTATION RESOURCE

国家生物医学计算资源

• 批准号: 8464170
• 负责人: Rommie E Amaro
• 金额: $ 212.88万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-05-06 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8464170
• 关键词: Active Sites; Address; Adopted; Adoption; Algorithms; Amino Acid Sequence; Architecture; Area; Biomedical Computing; Biomedical Engineering; Biomedical Research; Cardiac; Cause of Death; Cells; Clinical; Code; Communicable Diseases; Communities; Complex; Computational Biology; Computer Assisted; Computer Simulation; Computer software; Coupling; Data; Data Quality; Development; Disease; Educational workshop; Electron Microscopy; Ensure; Environment; Evolution; Feedback; Future; Genetic; Goals; Health; Heart Diseases; Heart failure; Image; Imagery; Individual; Information Technology; Institutes; Knowledge; Link; Long QT Syndrome; Mechanics; Methods; Mission; Modeling; Muscle Cells; Myocardial Ischemia; Operative Surgical Procedures; Patients; Pattern; Peptide Sequence Determination; Physiology; Process; Proteins; Reproducibility; Research; Research Personnel; Resources; Running; Scheme; Science; Scientist; Services; Software Tools; Solutions; Speed; Structure; Structure-Activity Relationship; Study models; Subcellular structure; Technology; Testing; Three-Dimensional Image; Training; Translational Research; United States; Ventricular; Ventricular Arrhythmia; Visual; Work; biomedical scientist; computerized tools; computing resources; distributed data; drug discovery; flexibility; frontier; improved; insight; instrument; macromolecule; meetings; models and simulation; molecular dynamics; multi-scale modeling; multidisciplinary; research and development; restoration; screening; simulation; simulation software; software development; tool; web services

NBCR's overarching mission is to conduct, catalyze, and enable biomedical research by harnessing forefront computational and information technologies, with a strong focus on translational and multiscale research. In the coming five years we see tremendous opportunities in biomedical research because of the continuing revolution in information technology and the abundance of computing availability. Our objectives are to advance the frontiers of our understanding in multiscale biomedical approaches; provide translational results of significance; accelerate the adoption and development of emerging information technologies by the, biomedical science community; continue to strengthen the multidisciplinarity of the resource; and create multidisciplinary communities of collaborators and users in key areas of translational research. We accomplish these goals through an interrelated set of activities: Integrate computational, data and visualization resources in a transparent way to enable better access to distributed data, computational resources, instruments and people; Develop and deploy advanced computational tools and packages for model building and simulation, three-dimensional image processing, and interactive visualization; Deliver and support advanced cyberinfrastructure tools and environments for biomedical researchers. Train a cadre of new researchers such that they have an interdisciplinary, working knowledge both of experimental biology and of computational technology relevant to biomedical scientists. In this renewal our core technology research and development activities will focus on three themes: 1. Multiscale Model Building and Visualization Tools, for data refinement, visual workflows, mathematical and visual modeling, available in appropriate toolkits and simulation packages. 2. Multiscale Simulation Software Packages and Pipelines for targeted biomedical and translational research to gain those insights into key biomedical processes and diseases, building on NBCR and partner tools and utilizing the cyberinfrastructure. 3. Flexible. Scalable Cvberinfrastructure Framework, to address practical issues of adopting and optimizing some exemplar biomedical applications to the current and emerging cyberinfrastructure while ensuring scientific reproducibility. These developments are driven by collaborative projects on translational research, and have broader impact on the community via service project that use our tools, training on our tools, and dissemination.

NBCR 的首要使命是通过利用前沿计算和信息技术来开展、促进和实现生物医学研究，重点关注转化和多尺度研究。在未来五年中，由于信息技术的持续革命和丰富的计算可用性，我们在生物医学研究中看到了巨大的机遇。我们的目标是推进我们对多尺度生物医学方法的理解前沿；提供有意义的翻译结果；加速生物医学界对新兴信息技术的采用和开发；继续加强资源的多学科性；并在转化研究的关键领域创建由合作者和用户组成的多学科社区。我们通过一系列相互关联的活动来实现这些目标： 以透明的方式集成计算、数据和可视化资源，以便更好地访问分布式数据、计算资源、仪器和人员；开发和部署先进的计算工具和软件包，用于模型构建和仿真、三维图像处理和交互式可视化；为生物医学研究人员提供和支持先进的网络基础设施工具和环境。培训一批新研究人员，使他们拥有与生物医学科学家相关的实验生物学和计算技术的跨学科工作知识。 在本次更新中，我们的核心技术研发活动将重点关注三个主题： 1. 多尺度模型构建和可视化工具，用于数据细化、可视化工作流程、 数学和视觉建模，可在适当的工具包和模拟包中使用。 2. 针对目标生物医学和转化的多尺度仿真软件包和管道 研究以 NBCR 为基础，深入了解关键的生物医学过程和疾病 合作伙伴工具并利用网络基础设施。 3、灵活。可扩展的网络基础设施框架，解决采用和实施的实际问题 针对当前和新兴的网络基础设施优化一些生物医学应用范例 同时保证科学的可重复性。 这些发展是由转化研究合作项目推动的，并通过使用我们的工具的服务项目、工具培训和传播对社区产生更广泛的影响。