DIAGNOSTIC ALGORITHM FOR NONHUMAN PRIMATE ALOPECIA

非人灵长类脱发的诊断算法

• 批准号: 8173038
• 负责人: KERITH LUCHINS
• 金额: $ 6.18万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173038
• 关键词: Adrenal Gland Hyperfunction; Aerobic; Affect; Algorithms; Alopecia; Anesthesia procedures; Animals; Area; Arthrodermataceae; Behavior; Behavioral; Biopsy; Blood; Chemistry; Complete Blood Count; Computer Retrieval of Information on Scientific Projects Database; Cytology; Dermatologic; Diagnosis; Diagnostic; Endocrine; Ensure; Evaluation; Funding; Grant; Hair; Histopathology; Hour; Hypothyroidism; Institution; Link; Medical; Methods; Pathogenesis; Pattern; Primates; Research; Research Personnel; Resources; Serum; Skin; Source; Surface; System; United States National Institutes of Health; Veterinarians; Veterinary Medicine; Videotape; inclusion criteria; meetings; nonhuman primate; psychologic

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: When nonhuman primates are found to have hair loss (alopecia), this is concerning for veterinarians, researchers, and the public. In addition, regulatory agencies have linked the occurrence of alopecia to the psychological wellbeing of nonhuman primates. Behavioral causes of alopecia have become the default diagnosis for captive primates; however, it is important to investigate the pathogenesis of alopecia including both medical and behavior causes to ensure the most accurate diagnosis and thus, proper treatment. The hypothesis of the study is that typical diagnostic algorithms used in domestic veterinary medicine are not applicable to diagnosing causes of alopecia in nonhuman primates. Methods: Animals that meet inclusion criteria will have the following performed under anesthesia: physical and dermatologic exams; alopecia degree and pattern scoring, using the US National Primate Research Centers Behavioral Management Consortium Alopecia Scoring System. Photographs of 4 views of the affected animal will be taken. Medical diagnostics will include blood draw for complete blood count, serum chemistry, and endocrine panel for hypothyroidism and for hyperadrenocorticism. From alopecic areas, surface skin cytology, dermatophyte culture, deep and superficial skin scrape, aerobic bacterial culture and skin biopsy for histopathology will be performed. Animals will then undergo a subsequent behavioral evaluation, which will include a total of 6 hours of videotaping to look for presence or absence of hair plucking.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 中心，不一定是研究者的机构。 简介：当发现非人类灵长类动物出现脱发（脱发）时，兽医、研究人员和公众都会感到担忧。 此外，监管机构已将脱发的发生与非人类灵长类动物的心理健康联系起来。行为原因引起的脱发已成为圈养灵长类动物的默认诊断。然而，重要的是调查脱发的发病机制，包括医学和行为原因，以确保最准确的诊断和正确的治疗。 该研究的假设是，国内兽医使用的典型诊断算法不适用于诊断非人类灵长类动物的脱发原因。 方法：符合纳入标准的动物将在麻醉下进行以下检查：身体和皮肤科检查；脱发程度和模式评分，采用美国国家灵长类研究中心行为管理联盟脱发评分系统。将拍摄受影响动物的 4 张照片。 医学诊断将包括抽血进行全血细胞计数、血清化学分析以及甲状腺功能减退症和肾上腺皮质功能亢进症的内分泌检查。对于脱发区域，将进行表面皮肤细胞学检查、皮肤癣菌培养、深层和浅层皮肤刮擦、需氧细菌培养和用于组织病理学的皮肤活检。 然后，动物将接受后续的行为评估，其中包括总共 6 小时的录像，以检查是否存在拔毛行为。