DIAGNOSTIC ALGORITHM FOR NONHUMAN PRIMATE ALOPECIA

非人灵长类脱发的诊断算法

• 批准号: 8358126
• 负责人: KERITH LUCHINS
• 金额: $ 3.72万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8358126
• 关键词: Algorithms; Alopecia; Animals; Behavior; Behavior assessment; Behavioral; Control Animal; Diagnosis; Diagnostic; Evaluation; Funding; Grant; Hair; Histopathology; Medical; National Center for Research Resources; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Source; Testing; United States National Institutes of Health; base; clinically relevant; companion animal; cost; design; nonhuman primate; psychologic

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. INTRODUCTION: Concerns regarding alopecia in nonhuman primates are justified given that hair performs many essential functions. METHODS: The occurrence of alopecia is often attributed to the level of psychological wellbeing, and behavioral causes have become a routine, unconfirmed default diagnosis for alopecia in captive nonhuman primates. However, before attributing alopecia to abnormal behavior, it is necessary to rule out medical causes of alopecia. In this study, a medical and behavioral assessment of animals with and without alopecia was performed with the aim of designing a guide to approaching cases of nonhuman primate alopecia. The well-established algorithm for evaluation of alopecia in companion animal species was used as the basis for the medical evaluation. In addition, a behavioral evaluation was used to assess animals for the presence or absence of hair plucking. The hypothesis tested was that the commonly used diagnostic evaluation for alopecia in companion animal species is not applicable to nonhuman primates. RESULTS/DISCUSSION: Aside from the histopathology and behavioral assessment differences, few clinically relevant significant differences were found between animals with alopecia and control animals. As a result, the hypothesis was confirmed and we determined that application of the diagnostic plan for alopecia that is used in companion animal species to nonhuman primates is a practice that needs to be reexamined.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 简介：鉴于毛发具有许多基本功能，对非人类灵长类动物脱发的担忧是合理的。方法：脱发的发生通常归因于心理健康水平，而行为原因已成为圈养非人类灵长类动物脱发的常规、未经证实的默认诊断。然而，在将脱发归因于异常行为之前，有必要排除脱发的医学原因。在这项研究中，对患有和不患有脱发的动物进行了医学和行为评估，目的是设计处理非人类灵长类脱发病例的指南。伴侣动物脱发评估的完善算法被用作医学评估的基础。此外，还使用行为评估来评估动物是否存在拔毛行为。测试的假设是，伴侣动物物种脱发的常用诊断评估不适用于非人类灵长类动物。结果/讨论：除了组织病理学和行为评估差异外，脱发动物和对照动物之间几乎没有发现临床相关的显着差异。结果，这一假设得到了证实，我们确定将伴侣动物物种中使用的脱发诊断计划应用于非人类灵长类动物是一种需要重新审查的做法。