Attention Training's Impact on Biobehavioral Correlates of Behavioral Inhibition

注意力训练对行为抑制的生物行为相关性的影响

基本信息

批准号：
8312487
负责人：
Koraly E Perez-Edgar
金额：
$ 43.7万
依托单位：
PENNSYLVANIA STATE UNIVERSITY, THE
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-08-04 至 2016-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8312487
关键词：
12 year old Address Adolescence Adolescent Adult Age Amygdaloid structure Anxiety Attention Behavior Behavioral Behavioral inhibition Biological Child Childhood Clinical Cognitive Cognitive Therapy Computers Corpus striatum structure Cues Data Detection Development Electroencephalogram Empirical Research Environment Environmental Risk Factor Event-Related Potentials Exhibits Foundations Functional Magnetic Resonance Imaging Functional disorder Geographic Locations Gold Health Services Accessibility Individual Intervention Laboratories Literature Measures Mental Depression Modification Monitor Neurosciences Outcome Participant Patient Self-Report Pattern Performance Placebos Play Prefrontal Cortex Procedures Process Protocols documentation Psychophysiology Reaction Recording of previous events Recruitment Activity Relative (related person)Remittance Reporting Research Resources Rest Risk Risk Factors Risk Marker Role Sampling Social Behavior Social Functioning Social Interaction Socioeconomic Status Stimulus Symptoms Temperament Time Training Withdrawal Work Writing base biobehavior developmental disease early childhood effective therapy endophenotype expectation experience improved information processing neuroimaging novel peer relating to nervous system response sex social stressor successful intervention theories trait young adult

12 year old Address Adolescence Adolescent Adult Age Amygdaloid structure Anxiety Attention Behavior Behavioral Behavioral inhibition Biological Child Childhood Clinical Cognitive Cognitive Therapy Computers Corpus striatum structure Cues Data Detection Development Electroencephalogram Empirical Research Environment Environmental Risk Factor Event-Related Potentials Exhibits Foundations Functional Magnetic Resonance Imaging Functional disorder Geographic Locations Gold Health Services Accessibility Individual Intervention Laboratories Literature Measures Mental Depression Modification Monitor Neurosciences Outcome Participant Patient Self-Report Pattern Performance Placebos Play Prefrontal Cortex Procedures Process Protocols documentation Psychophysiology Reaction Recording of previous events Recruitment Activity Relative (related person)Remittance Reporting Research Resources Rest Risk Risk Factors Risk Marker Role Sampling Social Behavior Social Functioning Social Interaction Socioeconomic Status Stimulus Symptoms Temperament Time Training Withdrawal Work Writing base biobehavior developmental disease early childhood effective therapy endophenotype expectation experience improved information processing neuroimaging novel peer relating to nervous system response sex social stressor successful intervention theories trait young adult

展开

项目摘要

DESCRIPTION (provided by applicant): Early childhood temperament, particularly behavioral inhibition (BI), is seen as an expression of a child's biologically based reaction tendencies to novelty and threat. Behaviorally inhibited children have difficulty with peer interactions and exhibit withdrawal in novel social situations. In addition, BI children are at increased risk for anxiety in adolescence and into young adulthood. While research has helped identify the most at-risk children, due to extreme temperament, environmental risk factors, or biological vulnerabilities, we do not have strong interventions that may help ameliorate risk. Indeed, front-line or gold-standard interventions such as cognitive-behavioral therapy (CBT) have remittance rates of only 50%. The adult literature suggests that targeting attention biases to threat may help lessen anxious behaviors in at-risk children. This work builds on cognitive theories of anxiety that focus on information processing biases as well as empirical research suggesting that attention biases to threat may play a causal role in the emergence of anxiety. Indeed, recent work has found that attention bias modification (ABM) protocols that train attention away from threat decrease anxious symptoms and improve an individual's response to a laboratory stressor. Previous work has shown numerous biobehavioral parallels between BI and anxiety, and new studies emerging in the last two years also find that BI children show attention biases to threat. The current study will for the first time examine the efficacy of a multi-week ABM protocol with children at temperamental risk for anxiety. To examine the breath of the potential ABM effect the study will assess biobehavioral correlates of BI and anxiety at baseline and after intervention (outcome). These markers include event-related potential (ERP) response to attention bias, the neural correlates (via fMRI) of attention bias, right frontal encephalogram (EEG) asymmetry at rest, social behavior in an encounter with an unfamiliar same-age, same-sex peer, and finally, parental- and self-report of anxious symptomotology. Three groups of 9 to 12-year-old children will participate: BI children who will undergo an active ABM protocol (BI-ABM), BI children undergoing an attention placebo (BI-Placebo) and non- inhibited children who will also experience a placebo (non-BI-Placebo). It is our expectation that both BI groups will display a biobehavioral pattern of risk at baseline. However, post-ABM we predict that the BI-ABM group will show less risk than their BI-Placebo counterparts and may even be comparable to the non-BI- Placebo group. If successful, this proof of concept study will provide evidence for a novel intervention that is portable, efficient, easily-implemented and can be used with very young children. This would broaden our ability to ameliorate suffering and broaden access to treatment across geographic location, socioeconomic status, and age.

描述（由申请人提供）：幼儿的气质，尤其是行为抑制（BI），被视为基于生物学的新颖性和威胁的基于生物学的反应趋势的表达。行为抑制的儿童在同伴相互作用方面难以进行，并且在新的社交情况下表现出戒断。此外，BI儿童在青春期和成年期的焦虑风险增加。尽管研究有助于确定最高危的儿童，但由于气质，环境风险因素或生物脆弱性，我们没有强大的干预措施可以帮助减轻风险。实际上，前线或金标准干预措施（例如认知行为疗法（CBT））的汇率仅为50％。成人文献表明，针对关注偏见威胁可能有助于减轻高危儿童的焦虑行为。这项工作以焦虑的认知理论为基础，该理论的重点是信息处理偏见以及实证研究，表明对威胁的关注偏见可能在焦虑的出现中起因果作用。确实，最近的工作发现，注意偏置修改（ABM）方案，这些方案训练注意力远离威胁会减少焦虑症状并改善个人对实验室压力源的反应。先前的工作表明，BI和焦虑之间有许多生物行为的相似之处，在过去的两年中，新的研究也发现BI儿童表现出对威胁的关注偏见。当前的研究将首次研究为期多周的ABM方案对儿童具有焦虑风险的儿童的功效。为了检查潜在的ABM效应的呼吸，研究将评估基线和干预后BI和焦虑的生物行为相关性（结果）。这些标记包括对注意力偏差的事件相关电位（ERP）反应，注意力偏置的神经相关性（通过fMRI），右额叶脑电图（EEG）在静止时的不对称性，社交行为，与不熟悉的同龄，同龄人，同性恋同伴，最终的焦虑症状学和自我报道的症状。三组9至12岁的孩子将参加：BI儿童将接受活跃的ABM方案（BI-ABM），BI儿童接受关注安慰剂（BI-PLASEBO）（BI-PLASEBO）和非抑制儿童，他们也会经历安慰剂（非Bi-placebo）。我们期望两个BI组在基线时都会显示出生物行为的风险模式。但是，ABM后我们预测，BI-ABM组的风险将比其Bi-placebo对应物较小，甚至可能与非BI-安慰剂组相提并论。如果成功的话，这项概念证明将为一种新颖的干预措施提供证据，该干预措施是便携式，高效，易于实施的，可以与很小的孩子一起使用。这将扩大我们改善痛苦和扩大跨地理位置，社会经济地位和年龄的治疗的能力。