NEURAL MECHANISMS OF SOCIAL COGNITION AND BONDING

社会认知和联系的神经机制

• 批准号: 8172403
• 负责人: Larry J Young
• 金额: $ 4.39万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172403
• 关键词: Amygdaloid structure; Animal Model; Autistic Disorder; Brain; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Cycloserine; Data; Drug Design; Female; Funding; Glutamate Agonist; Glutamates; Grant; Infusion procedures; Institution; Mental disorders; Nucleus Accumbens; Oxytocin; Pharmaceutical Preparations; Research; Research Personnel; Resources; Signal Transduction; Site; Source; United States National Institutes of Health; affiliative behavior; effective therapy; neuromechanism; prairie vole; preference; putamen; social attachment; social cognition

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We collected data demonstrating that the glutamate agonist, d-cycloserine facilitates social bond formation in prairie voles. D-cycloserine is a drug that has been used in clinical trials. We showed that peripherally administered D-cycloserine enhances partner preference formation in female prairie voles. This study was followed by site specific infusions the drug into the amygdala, nucleus accumbens and caudate putamen. Our results suggested that D-cycloserine infused into the nucleus accumbens and amygdala, but not into the caudate facilitates partner preference formation. These studies will have direct translational implications for designing drug treatments in autism. Prairie voles are an ideal animal model for investigating the brain mechanisms that regulate affiliative behavior and social bonding. We hypothesized that enhanced oxytocin and glutamate signaling in the brain may be an effective treatment for the disruption in social cognition in psychiatric disorders such as autism.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 我们收集的数据表明，谷氨酸激动剂 d-环丝氨酸有助于草原田鼠社会纽带的形成。 D-环丝氨酸是一种已用于临床试验的药物。 我们发现外周注射 D-环丝氨酸可增强雌性草原田鼠伴侣偏好的形成。 这项研究随后将药物特定部位输注到杏仁核、伏隔核和尾壳核中。 我们的结果表明，D-环丝氨酸注入伏核和杏仁核，但不注入尾状核，有利于伴侣偏好的形成。 这些研究将对设计自闭症药物治疗具有直接的转化意义。 草原田鼠是研究调节亲和行为和社会联系的大脑机制的理想动物模型。 我们假设，增强大脑中的催产素和谷氨酸信号传导可能是治疗自闭症等精神疾病中社会认知障碍的有效治疗方法。