Developmental Projects and Trans-Alliance Activities

发展项目和跨联盟活动

• 批准号: 7984294
• 负责人: Vladimir P Torchilin
• 金额: $ 6.7万
• 依托单位: NORTHEASTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7984294
• 关键词: Address; Animal Model; Behavior; Bioinformatics; Biological; Budgets; CCNE1 gene; Clinical; Collaborations; Data; Development; Funding; Future; Goals; Image; Imaging technology; Individual; Institution; Joints; Knowledge; Literature; Malignant Neoplasms; Pharmaceutical Preparations; Pilot Projects; Procedures; Production; Research; Scheme; Scientist; Testing; Time; Work; base; drug candidate; expectation; experience; manufacturing facility; manufacturing scale-up; meetings; nanocarrier; nanomedicine; novel; peer; scale up; success

Although, the aims and goals of the individual projects as well as of the Center as a whole are quite clear, the usual flow of research, especially, with such a broad approach and with the involvement of multiple coordinated groups, will certainly generate some important questions, which have to answered for the success of the whole project, but were not addressed in the aims of the initial individual projects. In such cases, we will initiate specific short term (from 6 months to a year) Pilot Projects to be performed within one of Center's component on a competitive basis, since this will be involving an additional funding. The need for such projects should be cleariy established by discussing the needs of the Center by the Internal Executive Committee with the assistance of the External Advisory Board. As soon as the need for such Pilot Project is cleariy established, all individual project leaders will be informed about such a need and given with short but sufficient time (from 2 to 4 weeks) to submit their proposal (2-to-3 pages long) and appropriate budgets. Within the next two weeks the decision will be made by the Executive Committee together with the Advisory Board and the best proposal will be funded from a set aside funds (as requested by the NCI). Hypothetical examples of such Pilot Proiects mav include: ¿ Development and testing new type of a nanocarrier if the initially selected one does not meet the initial expectation; ¿ Development and testing a novel loading procedure if the initially used one provides less than optimal drug load; ¿ Testing of a certain nanopreparation in another animal model than initially suggested, if the initially suggested one does not perform good enough for whatever reason; ¿ Need to develop any alternative approach based on the data from Nanocharacterization and/or Imaging Cores; ¿ Need to make an additional research, which can arise from any recent literature data to adjust Center's projects according to newly available scientific information. Such Pilot Project can also serve as a mechanism to involve new junior scientists from the host institutions in the Center's activities. Trans-Alliance activities (Challenge projects). One can easily foresee that actively working CCNE will be generating new knowledge and ideas, the full scale use and/or implementation of which will not be entirely possible within the frame of the host CCNE. Natural development in this case is the creation of working connections and joint projects between different CCNEs to address such issues and respond the arising need fast and effectively. Clearly, in this case all CCNEs should about the unique capabilities of their peers to help with be infonned choosing a proper partner. This type of the information should be disseminated via the corresponding Bioinformatics Units or Cores. The unique capabilities of the future Center for Translational Cancer Nanomedicine suggested by us include: 1. Excellent facilities and broad experience of our Imaging Core (see the detailed Core description in the Center Organization Section as well as in the specific Imaging Core description), which could be used for various joint projects; 2. The involvement of the GMP Scaling Up and Manufacturing facility (see the detailed Core description in the Center Organization Section as well as in the specific Manufacturing Core description), which can be used for various joint projects if other CCNEs will need to test the possibilities of industrial scaling up and manufacturing of their drug candidates. Thus, the proposed Center for Translational Cancer Nanomedicine will be capable of Trans-Alliance collaboration on the study of the biological behavior of various nanomedicines by using a cutting edge imaging technologies, on the development of novel imaging agents for cancer, and on the development of industrial production schemes for a broad set of various nanomedicines with good clinical promise.

尽管各个项目以及整个中心的目的和目标都非常明确，但通常的研究流程，特别是采用如此广泛的方法和多个协调小组的参与，肯定会产生一些重要的成果。为了整个项目的成功而必须回答的问题，但在最初的单个项目的目标中没有得到解决。在这种情况下，我们将启动要执行的特定短期（从 6 个月到一年）试点项目。在竞争的基础上，在中心的一个组成部分内，因为这将涉及额外资金。 此类项目的需求应通过内部执行委员会在外部咨询委员会的协助下讨论中心的需求来明确确定。一旦明确确定了此类试点项目的需求，将通知所有个别项目负责人。并给予短暂但充足的时间（2 至 4 周）来提交提案（2 至 3 页）和适当的预算，执行委员会将在接下来的两周内共同做出决定。与顾问委员会合作，最佳提案将由预留资金提供资金（根据 NCI 的要求）。 此类试点项目的假设示例包括： ¿如果最初选择的纳米载体不符合最初的期望，则开发和测试新型纳米载体； ¿如果最初使用的载药量未达到最佳载药量，则开发和测试一种新的载药量； ¿在另一种动物模型中测试某种纳米制剂，而不是最初建议的，如果 表明某人由于某种原因表现不够好； ¿需要根据纳米表征和/或成像核心的数据开发任何替代方法； ¿需要进行额外的研究，这可以从任何最近的文献数据中得出，以便根据新获得的科学信息调整中心的项目。 此类试点项目还可以作为一种机制，让主办机构的新青年科学家参与中心的活动。 跨联盟活动（挑战项目）。 人们可以很容易地预见到，积极工作的 CCNE 将产生新的知识和想法，而在宿主 CCNE 的框架内，这些知识和想法的全面使用和/或实施将是不可能的，在这种情况下，自然发展就是建立工作联系。以及不同 CCNE 之间的联合项目，以解决此类问题并快速有效地响应新出现的需求。 显然，在这种情况下，所有 CCNE 都应该了解其同行的独特能力，以帮助选择合适的合作伙伴。此类信息应通过相应的生物信息学单位或核心进行传播。 我们建议的未来转化癌症纳米医学中心的独特功能包括： 1.我们的成像核心拥有优良的设施和丰富的经验（参见中心组织部分的详细核心描述以及具体的成像核心描述），可用于各种联合项目； 2. GMP 放大和制造设施的参与（参见中心组织部分的详细核心描述以及具体的制造核心描述），如果其他 CCNE 需要测试该设施，则可用于各种联合项目工业规模扩大和生产候选药物的可能性。 因此，拟议的转化癌症纳米医学中心将能够跨联盟 双方合作利用尖端成像技术研究各种纳米药物的生物学行为，开发新型癌症显像剂，以及开发具有良好临床前景的各种纳米药物的工业生产方案。