Oxytocin Treatment of Social Cognitive and Functional Deficits in Schizophrenia

催产素治疗精神分裂症的社会认知和功能缺陷

• 批准号: 8417003
• 负责人: CORT ANDREW PEDERSEN
• 金额: $ 52.7万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-15 至 2015-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8417003
• 关键词: Acute; Aftercare; Animal Experimentation; Animal Model; Antipsychotic Agents; Anxiety; Applied Research; Behavior; Belief; Biological; Clinic; Cognition; Cognitive; Collaborations; Disease; Double-Blind Method; Effectiveness; Emotions; Empathy; Employment; Exhibits; Eye; Face; Functional disorder; Human; Impairment; Individual; Intervention; Intervention Studies; Intranasal Administration; Investigation; Lead; Life; Link; Measures; Mind; Motivation; National Institute of Mental Health; Neuropeptides; Outcome; Oxytocin; Paranoia; Patients; Perception; Performance; Pharmaceutical Preparations; Pilot Projects; Placebo Control; Placebos; Play; Process; Psyche structure; Randomized; Refractory; Reporting; Research; Resources; Rewards; Role; Schizophrenia; Scientist; Social Functioning; Strategic Planning; Study Section; Symptoms; Testing; Therapeutic Effect; Time; Trust; base; clinically relevant; digital; disability; follow-up; improved; informant; innovation; mental health center; placebo controlled study; pre-clinical; psychosocial; public health relevance; response; social; social cognition; social skills; theories; therapy design; treatment duration; treatment program; treatment trial; week trial

DESCRIPTION (provided by applicant): Deficits in social functioning are a hallmark of schizophrenia, the major cause of long-term disability in this disorder, and remain refractory to currently available antipsychotic medications. Social dysfunction in schizophrenia has been strongly linked to impaired social cognition, a set of cognitive abilities that include emotion recognition, attributional style and theory of mind. Oxytocin (OT) has been shown by decades of animal research to have numerous pro-social effects. OT also exerts antipsychotic-like efficacy in animal models of schizophrenia. In recent human studies, intranasal administration of OT increased interpersonal trust and eye contact as well as improved emotion recognition and theory of mind in normal subjects. Based on these prior findings, we hypothesized that OT treatment may improve social deficits and psychotic symptoms in schizophrenia. In a 2-wk randomized, double blind, placebo-controlled pilot study, we found that twice daily intranasal administration of OT (N=8), but not placebo (N=6), significantly 1) decreased PANSS total scores as well as scores on suspiciousness and other social function-relevant PANSS items, 2) decreased subject ratings on the Paranoia Scale and 3) improved accurate identification of second order false beliefs in the Br|ne test of theory of mind, among patients with schizophrenia. We now propose a 12-wk treatment trial to determine over this more clinically relevant period whether OT treatment will 1) further improve social cognition, 2) improve social functioning and 3) further decrease other psychotic symptoms. The proposed research is a unique translational collaboration between a basic behavior neuroscientist with expertise in OT (Dr. Cort Pedersen) and an applied research scientist with expertise in social cognition and psychosocial treatment in schizophrenia (Dr. David Penn). This project may demonstrate that OT has therapeutic effects that are superior to current antipsychotic medications (especially improvement in social cognition and social functioning) and open a new front in the investigation of the pathophysiology of schizophrenia.

描述（由申请人提供）：社交功能的缺陷是精神分裂症的标志，这是该疾病长期残疾的主要原因，并且仍然难以忍受目前可用的抗精神病药物。精神分裂症中的社会功能障碍与社会认知受损有很密切相关，社会认知能力包括情感识别，归因风格和心理理论。数十年来动物研究表明，催产素（OT）具有多种亲社会作用。 OT还在精神分裂症的动物模型中发挥抗精神病药样疗效。在最近的人类研究中，OT的鼻内给药增加了人际信任和眼神交流，以及改善正常受试者的情绪识别和心理理论。根据这些先前的发现，我们假设OT治疗可以改善精神分裂症的社会缺陷和精神病症状。 In a 2-wk randomized, double blind, placebo-controlled pilot study, we found that twice daily intranasal administration of OT (N=8), but not placebo (N=6), significantly 1) decreased PANSS total scores as well as scores on suspiciousness and other social function-relevant PANSS items, 2) decreased subject ratings on the Paranoia Scale and 3) improved accurate identification of second order false beliefs in the精神分裂症患者中的心理理论检验。现在，我们提出了一项12周的治疗试验，以确定在这个更临床相关的时期中，是否会进一步改善社会认知，2）改善社交功能，3）进一步减轻其他精神病症状。拟议的研究是具有OT专业知识的基本行为神经科学家（Cort Pedersen博士）的独特转化合作与精神分裂症社会认知和社会心理治疗方面的专业知识的应用研究科学家（David Penn博士）。该项目可能表明，OT具有优于当前抗精神病药物（尤其是社会认知和社会功能的改善）的治疗作用，并在研究精神分裂症病理生理学的研究中开辟了新的方面。

项目成果

Effects of oxytocin on empathy, introspective accuracy, and social symptoms in schizophrenia: A 12-week twice-daily randomized controlled trial.

• DOI: 10.1016/j.schres.2018.09.013
• 发表时间: 2019-03
• 期刊: Schizophrenia research
• 影响因子: 4.5
• 作者: Halverson T;Jarskog LF;Pedersen C;Penn D
• 通讯作者: Penn D

A 12-week randomized controlled trial of twice-daily intranasal oxytocin for social cognitive deficits in people with schizophrenia.

• DOI: 10.1016/j.schres.2017.01.008
• 发表时间: 2017-07
• 期刊: Schizophrenia research
• 影响因子: 4.5
• 作者: Jarskog LF;Pedersen CA;Johnson JL;Hamer RM;Rau SW;Elliott T;Penn DL
• 通讯作者: Penn DL

Schizophrenia and alcohol dependence: diverse clinical effects of oxytocin and their evolutionary origins.

精神分裂症和酒精依赖：催产素的不同临床作用及其进化起源。

• DOI: 10.1016/j.brainres.2014.01.050
• 发表时间: 2014
• 期刊: Brain research
• 影响因子: 2.9
• 作者: Pedersen,CortA

Racial disparities and predictors of functioning in schizophrenia.

种族差异和精神分裂症功能的预测因素。

• DOI: 10.1037/ort0000661
• 发表时间: 2023
• 期刊: The American journal of orthopsychiatry
• 作者: Merritt,CarringtonC;Halverson,TateF;Elliott,Tonya;Jarskog,LFredrik;Pedersen,CortA;Penn,DavidL
• 通讯作者: Penn,DavidL