Oxytocin, Postnatal Experience & Adult Maternal Behavior

催产素，产后经历

• 批准号: 6856586
• 负责人: CORT ANDREW PEDERSEN
• 金额: $ 32.74万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-15 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6856586
• 关键词: aggression; anxiety; behavior test; behavioral /social science research tag; biological models; brain mapping; ethology; experience; hormone receptor; hormone regulation /control mechanism; laboratory rat; lactation; maternal behavior; mother child interaction; mother deprivation; neurobiology; oxytocin; psychosocial separation; receptor binding; social behavior

DESCRIPTION (provided by applicant): In human and non-human primates, decades of clinical and research findings clearly show that nurturing received during infancy and childhood influences the quality of parental and other social behaviors as well as the ability to cope with stress during adulthood. Recent studies of early maternal separation effects in rats demonstrate that postnatal nurturing also shapes adult social behavior and stress responses in lower mammals. This rodent model permits more detailed investigation of the mechanisms underlying these life-long consequences of early experience than is feasible in primates. In Preliminary Studies, rat dams subjected to brief and long daily maternal separations (BMS vs. LMS) during infancy exhibited, respectively, increased and decreased pup-grooming (PG), maternal aggression and lactation-associated declines in anxiety. These behavioral differences were related to contrasting effects of the BMS and LMS procedures on the amount of maternal care dams received from their mothers. Mothers subjected to brief and long daily pup-separations exhibited respectively increased and decreased PG and arched-back nursing (ABN). Preliminary Studies and other recent evidence indicate that central oxytocin (OT) regulates behaviors that differ between rat dams with contrasting postnatal MS experience and these early experiences are associated with significant differences in OT receptors in brain sites where OT exerts these behavioral effects. These findings suggest the following model of MS effects on mothers and their female offspring. Central OT enhances lactating rat mothers' PG and ABN. Daily brief and long pup-separations (BMS and LMS procedures) respectively raise and lower mothers' PG and ABN by increasing and decreasing central OT enhancement of these maternal behaviors. Dams' PG and ABN frequencies subsequently determine the degree of OT regulation of behavior that develops in female offspring, which influences their adult PG and ABN frequencies as well as lactation-associated changes in aggression and anxious behavior. The proposed Experiments will test this model by pursuing five Specific Aims. Specific Aim 1 is to examine in more detail the relationships between postnatal BMS and LMS and dams' maternal behavior, aggression, lactation changes in anxiety and central OT receptor binding. Specific Aims 2, 4, and 5 are to determine whether differences in the degree of central OT regulation of PG, ABN, maternal aggression and anxiety contribute to contrasting levels of these behaviors between mothers with postnatal BMS vs. LMS experience. Brain sites in which OT stimulates PG and ABN will also be sought. Aim 3 is to determine whether upswings and downswings in PG-ABN in mothers subjected to brief and long daily pup-separations are the respective results of increased and decreased OT enhancement of these behaviors.

描述（由申请人提供）：在人类和非人类灵长类动物中，数十年 临床和研究结果清楚地表明，在 婴儿期和童年影响父母和其他社会的质量 行为以及成年期应对压力的能力。最近的 大鼠早期母体分离效应的研究表明，产后 培养还塑造了成人的社会行为和压力反应 哺乳动物。这种啮齿动物模型允许对 这些早期经验的终生后果的基础机制比IS 在灵长类动物中可行。 在初步研究中，大鼠大坝经历了短暂而长的每日母亲 婴儿期分离（BMS与LMS）分别表现出来，并增加 减少幼崽环（PG），母体侵略和哺乳期相关的 焦虑的下降。这些行为差异与对比有关 BMS和LMS程序对孕产妇护理水坝量的影响 从母亲那里收到。母亲每天都有短暂而漫长的 幼崽分离分别表现出pg的增加和减少，并且 拱形护理（ABN）。 初步研究和其他最近的证据表明中央催产素 （ot）调节大鼠大坝之间不同的行为与形成鲜明对比 产后MS经验和这些早期经验与 OT在OT施加这些受体的OT受体的显着差异 行为影响。这些发现提出了以下MS对影响的模型 母亲及其女性后代。中央OT增强了哺乳后的大鼠母亲的 PG和ABN。每日简短和长幼崽分离（BMS和LMS程序） 通过增加和减少来分别提高和下降母亲的PG和ABN 这些孕产妇行为的中心OT增强。大坝的PG和ABN 频率随后确定行为的OT调节程度 在女性后代发展，影响其成人PG和ABN 频率以及与哺乳相关的侵略性变化和焦虑 行为。 提出的实验将通过追求五个特定目标来测试该模型。 具体目标1是更详细地检查产后之间的关系 BMS和LMS和大坝的孕产妇行为，侵略性，泌乳的变化 焦虑和中央OT受体结合。具体目标2、4和5是 确定PG中心OT调节程度的差异是否存在 ABN，母亲的侵略和焦虑有助于对比的对比水平 有产后BMS与LMS经验的母亲之间的行为。大脑部位进入 也将寻求刺激PG和ABN的OT。目标3是确定 是否有摘要和 长期每日幼崽分离是增加和 降低了这些行为的OT增强。