Risk Factors for Nevus Development in Children

儿童痣形成的危险因素

• 批准号: 8210919
• 负责人: LORI A. CRANE
• 金额: $ 54.37万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-15 至 2015-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8210919
• 关键词: Adolescence; Age; Behavior; Behavioral; Behavioral Genetics; Benign; Biological; Birth; Child; Childhood; Clinical; Cohort Studies; Collection; Color; Data; Data Collection; Development; Environmental Exposure; Eye Color; Freckles; Funding; Gender; Genes; Genetic; Genetic Markers; Genetic Polymorphism; Genotype; Growth; Growth and Development function; Hair Color; Human; Individual; Intervention Studies; Interview; Lead; Life Cycle Stages; Longevity; Longitudinal Studies; Measurement; Mole the mammal; Nature; Nevi and Melanomas; Nevus; Newborn Infant; Parents; Participant; Pathway interactions; Patient Self-Report; Pattern; Pigmentation physiologic function; Prevention; Preventive; Procedures; Puberty; Public Health; Recommendation; Recruitment Activity; Research; Research Personnel; Risk; Risk Factors; Running; Saliva; Sampling; Shapes; Site; Skin; Skin Pigmentation; Skin tanning; Sun Exposure; Sunburn; Telephone Interviews; The Sun; Time; UV Radiation Exposure; cohort; critical period; design; early childhood; gene interaction; genome wide association study; insight; meetings; melanocyte; melanoma; prevent; protective behavior; public health relevance; social; sun protection; trait; tumor

DESCRIPTION (provided by applicant): Both malignant melanoma and nevi (moles) arise from melanocytes, and in many cases, nevi are thought to be intermediate in the pathway from melanocyte to melanoma. The presence of nevi is the strongest predictor of melanoma risk, and individuals who have higher numbers of nevi have an estimated 6 to 7-fold increased risk of developing malignant melanoma. Most nevi are developed in childhood and an understanding of the genetic, environmental, and behavioral factors that contribute to nevus development and growth is essential for understanding the pathways to melanoma. This study began in 1998 with a sun protection intervention study of newborns, in which sun exposure and sun protection data were collected beginning at birth and nevus exams were conducted starting at age 3. In 2004, additional children were added to the cohort, for which sun exposure, sun protection, and skin exam data were collected annually at ages 6-10. This study is now the longest running annual longitudinal study of childhood nevus development in the world. The overall aim of this project is to continue studying this cohort (n=936) with nevus counts and interviews for five additional years, from 2010 - 2014, and to add two new data collection components: a genetic component and more detailed data collection on changes in growth and shape of individual nevi. Previous research indicates that the 12 - 16 age range covered by the 2010 - 2014 funding period will be the most critical period for emergent nevi during the lifespan. This study will examine increases in number of nevi, and changes in individual nevi, and how these are influenced by the interaction of genes, UV exposure, and sun protection behavior during this critical period. Up to 100 SNPs in genes already known to be associated with nevi or identified recently through genome wide studies (conducted by other researchers) as related to pigmentation, nevus development, or melanoma will be assessed. The comprehensive nature of the data collected through age 10, the data that will be collected during the course of the proposed study, and the availability of newly described genes that influence human pigmentation, nevus development and melanoma will allow for the most complete analysis of influences on nevus formation yet undertaken. The long-term clinical and public health significance of this research include: 1) a better understanding of the biological mechanisms that result in both nevus and melanoma development, which could lead to new treatments for melanoma; 2) possible chemo-preventive agents to prevent nevus development and/or melanoma; and 3) more targeted public health recommendations regarding sun protective behaviors. PUBLIC HEALTH RELEVANCE: Nevi (moles) are markers of melanoma risk, and in some cases are precursors of melanoma. This project will examine the genetic, environmental, and behavioral risk factors for nevus development in children. Understanding of these factors will lead to a better understanding of melanoma, and may suggest approaches for melanoma prevention or treatment.

描述（由申请人提供）：恶性黑色素瘤和NEVI（痣）均来自黑色素细胞，在许多情况下，NEVI被认为是从黑色素细胞到黑色素瘤的途径中间的。 NEVI的存在是黑色素瘤风险的最强预测指标，而NEVI数量较高的个体估计有6至7倍的患者患恶性黑色素瘤的风险增加了6至7倍。大多数NEVI都是在童年时期发展的，并且对有助于奈弗斯发育和生长的遗传，环境和行为因素的理解对于理解黑色素瘤的途径至关重要。这项研究始于1998年，是针对新生儿的防晒干预研究，其中从出生时开始收集日晒和防晒数据，并从3岁开始进行了Nevus考试。2004年，在该队列中添加了更多的儿童，每年在6-10岁时收集日晒，防晒和皮肤检查数据。这项研究现在是全球儿童颈部发展的年度最长的年度纵向研究。该项目的总体目的是继续研究该队列（n = 936），其中包括Nevus的数量和访谈五年，从2010年至2014年，并添加了两个新的数据收集组件：遗传成分和更详细的数据收集有关个人Nevi的生长和形状的变化。先前的研究表明，2010年至2014年资金期限涵盖的12-16岁年龄段将是一生中新兴NEVI的最关键时期。这项研究将检查NEVI的数量增加以及单个NEVI的变化，以及这些关键时期内基因，紫外线暴露和防晒行为的相互作用的影响。将评估已知与NEVI相关的基因或最近通过基因组广泛研究（由其他研究人员进行的）鉴定的基因，该基因将评估与色素沉着，Nevus发育或黑色素瘤有关的基因。通过10岁的数据收集的数据的全面性质，在拟议的研究过程中将收集的数据，以及影响人类色素沉着，尼VUS发育和黑色素瘤的新描述的基因的可用性，将允许对尚未进行的NIVUS形成的影响进行最完整的分析。这项研究的长期临床和公共卫生意义包括：1）更好地理解导致奈弗斯和黑色素瘤发育的生物学机制，这可能会导致黑色素瘤的新治疗； 2）可能预防化学剂，以防止奈夫发育和/或黑色素瘤； 3）有关太阳保护行为的更多针对性的公共卫生建议。 公共卫生相关性：Nevi（痣）是黑色素瘤风险的标志，在某些情况下是黑色素瘤的前体。该项目将检查儿童奈夫发育的遗传，环境和行为风险因素。对这些因素的了解将导致对黑色素瘤的更好理解，并可能提出预防黑色素瘤或治疗的方法。