Investigating Molecular-Genetic Correlates of Fatigue

研究疲劳的分子遗传学相关性

• 批准号: 8554730
• 负责人: Leorey Saligan
• 金额: $ 16.74万
• 依托单位: NATIONAL INSTITUTE OF NURSING RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8554730
• 关键词: Aerobic Exercise; Affective; Behavioral; Biological Markers; Cancer Patient; Cognitive; Collection; Data; Dimensions; Disease; Emotional; Energy Metabolism; Exercise; External Beam Radiation Therapy; Fatigue; Gene Expression; Goals; Hour; IL8 gene; Impaired cognition; Incidence; Individual; Inflammatory; Insulin-Like Growth Factor I; Interleukin-6; Intervention; Leukocytes; Life Experience; Long-Term Effects; Longitudinal Studies; Malignant Neoplasms; Malignant neoplasm of prostate; Measures; Mental Depression; Molecular Genetics; Observational Study; Oxidative Stress; Patient Self-Report; Patients; Physical activity; Physiological; Population; Prostatectomy; Psyche structure; Radiation therapy; Risk; Sensory; Severities; Sex Functioning; Skeletal Muscle; Symptoms; TNF gene; Time; Training; cytokine; experience; gastrointestinal; gastrointestinal symptom; health related quality of life; muscle strength; patient population; programs; prospective; prostate surgery; theories; urinary

Although the underlying mechanisms of fatigue have been studied in several disease conditions, the data are not conclusive, and this symptom remains poorly managed at present. Longitudinal studies related to treatment-related fatigue in prostate cancer patients have been conducted, but there are limited studies exploring the changes in physiologic mechanisms before and after radiotherapy which can identify individuals who are at risk for enduring fatigue during and after therapy. Fatigue is conceptualized as a multidimensional symptom which incorporates temporal, sensory, cognitive/mental, affective/emotional, behavioral, and physiological dimensions. This prospective, observational study is the first study to explore the molecular-genetic mechanisms underlying fatigue and the cluster of symptoms (urinary, sexual, gastrointestinal, psychiatric) experienced by prostate cancer patients undergoing External Beam Radiation Therapy (EBRT). The primary objective of the study is to describe the changes in the self-reported fatigue; urinary, sexual, and gastrointestinal symptoms; depression; fatigue catastrophizing; and health-related quality of life (HRQOL) experienced by patients with and without prostate surgery before, during, and after EBRT completion. The secondary objectives of this study are to investigate the pro-inflammatory cytokine profile of EBRT-related fatigue (TNF, IGF-I, IL-6, IL-8, TGF and ) and to determine changes in white blood cell gene expression using buffy coat collection before, during, and after EBRT completion and to relate these changes in the levels of these biological markers to self-reported fatigue; urinary, sexual, and gastrointestinal symptoms; depression; fatigue catastrophizing; and HRQOL scores. This study also aims to measure the skeletal muscle strength, activity levels and energy expenditure of patients before, during, and at completion of EBRT and relate these findings with self-reported fatigue, physical symptoms (e.g. urinary, gastrointestinal, and sexual functioning), depression, and HRQOL scores.

尽管已经在几种疾病状况下研究了疲劳的潜在机制，但数据尚无定论，目前该症状仍然管理不善。已经进行了与前列腺癌患者中与治疗相关疲劳有关的纵向研究，但是有限的研究有限地探讨放疗前后的生理机制变化，这些变化可以鉴定出在治疗期间和治疗后持续疲劳风险的人。疲劳被概念化为多维症状，其中包含时间，感觉，认知/心理，情感/情感，行为和生理方面。这项前瞻性观察性研究是探索疲劳和症状簇（尿，性，胃肠道，精神病）的第一个研究，该研究是前列腺癌患者经历了外部束放射治疗（EBRT）。 该研究的主要目的是描述自我报告的疲劳的变化。尿，性和胃肠道症状；沮丧;疲劳灾难性；与健康相关的生活质量（HRQOL）在EBRT完成之前，期间和之后经历了有或没有前列腺手术的患者。这项研究的次要目标是研究与EBRT相关疲劳（TNF，IGF-I，IL-6，IL-6，IL-8，TGF和TGF和）的促炎细胞因子谱，并确定白细胞基因表达的变化，使用Buffy Coat在EBRT完成之前和之后，在EBRT完成并在这些生物学层次上进行了这些变化，以使这些生物学效果层次降低了这些级别的层次。尿，性和胃肠道症状；沮丧;疲劳灾难性；和HRQOL分数。 这项研究还旨在衡量EBRT之前，期间和完成患者的骨骼肌强度，活性水平和能量消耗，并将这些发现与自我报告的疲劳，身体症状（例如尿，胃肠道和性功能），抑郁症和HRQOL评分相关。