The Role of High Intensity Interval Training in the Treatment of Adolescent Obesity

高强度间歇训练在治疗青少年肥胖中的作用

• 批准号: 9387206
• 负责人: Edmond Pryce Wickham
• 金额: $ 20.4万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-02 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9387206
• 关键词: Accelerometer; Adherence; Adolescence; Adolescent; Adolescent obesity; Adult; Aerobic; Aerobic Exercise; Affective; African American; Age; Behavior monitoring; Behavioral; Blood Pressure; Body Composition; Body Weight; Body Weight decreased; Body fat; Body mass index; Cardiovascular system; Child; Childhood; Clinical Research; Comorbidity; Data; Diabetes Mellitus; Diet; Diet Modification; Drops; Dual-Energy X-Ray Absorptiometry; Enrollment; Epidemic; Exercise; Exercise stress test; Exertion; Family; Fasting; Frequencies; Goals; Guidelines; Health; Health Benefit; Heart Rate; Heterogeneity; Hour; Individual; Interval training; Intervention; Investigation; Length; Lipids; Literature; Measures; Methodology; Methods; Monitor; OGTT; Obesity; Overweight; Oxygen; Participant; Patient Self-Report; Physical activity; Prevention; Protocols documentation; Randomized; Randomized Controlled Trials; Recovery; Reporting; Research Design; Rest; Risk Factors; Role; Self Efficacy; Strenuous Exercise; Supervision; Time; Training; Training Activity; Training Programs; Weight; Weight Gain; Weight maintenance regimen; Youth; base; cardiometabolic risk; cardiorespiratory fitness; design; displeasure; effective intervention; exercise intensity; exercise program; exercise training; fitness; follow-up; improved; insulin sensitivity; interest; intervention program; lifestyle intervention; moderate-to-vigorous physical activity; multidisciplinary; obesity in children; obesity treatment; physical inactivity; pleasure; post intervention; programs; research study; sex; standard of care; therapeutic target; treadmill; weight maintenance

PROJECT SUMMARY/ABSTRACT: Family-based lifestyle interventions that combine dietary modification, physical activity (PA), and behavioral support are the standard of care for pediatric obesity treatment; however, methodologic heterogeneity across studies make it difficult to determine which specific strategies are most efficacious. Although interventions targeting PA alone result in limited weight loss, the health benefits of PA are extensive; and, interventions that combine PA training with dietary changes appear to have the most robust impact on weight. Thus, PA remains a key therapeutic target for the primary treatment of pediatric obesity. The importance of effective interventions that target PA may be particularly salient during adolescence, when PA levels decline dramatically. Although guidelines endorse the importance of regular, continuous moderate-to- vigorous PA, the ideal components of an age-appropriate activity program, including the required exercise intensity, have not yet been well-established, particularly for adolescents. High-intensity interval training (HIIT) which consists of repeated brief bouts of high-intensity PA with intervening short periods of recovery may be particularly efficacious in improving health as it requires less time than more traditional aerobic training. Despite a growing literature that supports HIIT training as safe and effective in improving body composition and cardiorespiratory fitness among adults, fewer studies have investigated the role of HIIT in children and adolescents, particularly in the context of the comprehensive obesity treatment using a rigorous study design. As a result, this application proposes to conduct a pilot randomized controlled trial to determine the feasibility and preliminary efficacy of integrating two distinct approaches to exercise training within an established lifestyle intervention for adolescent obesity. Specifically, 56 adolescents, age 12-16 years, with obesity participating in a 12-week lifestyle intervention will be randomly assigned to participation in one of two exercise training session conditions: 1) high-intensity interval training (HIIT) or 2) continuous, moderate-intensity training (CMIT). Both exercise programs will consist of three supervised sessions per week. In addition, all adolescents will participate in weekly behavioral weight management sessions that target specific dietary goals and promote self-monitoring behaviors. Assessments will be completed at baseline, post-intervention (12 weeks), and 1-month follow-up (16 weeks). Study results will be used to 1) determine the feasibility and acceptability of HIIT and CMIT as part of a comprehensive lifestyle intervention for adolescents with obesity; 2) investigate the preliminary efficacy of HIIT, compared with energy-matched CMIT, on adolescent adiposity, cardiorespiratory fitness and cardiometabolic risk factors; and, 3) explore if exercise training conditions (HIIT or CMIT) influence short-term PA levels and weight maintenance after completion of the lifestyle intervention. Results of these preliminary investigations will inform a fully powered trial examining the role of HIIT in the comprehensive treatment of adolescent obesity.

项目摘要/摘要：结合饮食修改的基于家庭的生活方式干预措施， 体育活动（PA）和行为支持是小儿肥胖治疗的护理标准；然而， 跨研究的方法论异质性使得难以确定哪些特定策略最多 有效。尽管仅针对PA的干预措施导致体重减轻有限，但PA的健康益处是 广泛的;而且，将PA培训与饮食变化结合的干预措施似乎具有最强大的 对体重的影响。因此，PA仍然是小儿肥胖主要治疗的关键治疗靶点。这 靶向PA的有效干预措施的重要性可能在青春期特别重要，当 水平急剧下降。尽管准则认可常规，连续中度到 - 的重要性 剧烈PA是适合年龄的活动计划的理想组成部分，包括所需的练习 强度尚未建立良好的，尤其是对于青少年。高强度间隔训练（HIIT） 这包括在短期恢复时期反复的高强度PA的短暂发作可能是 比传统的有氧训练需要更少的时间来改善健康，因为它需要更少的时间。尽管 越来越多的文献支持HIIT培训可以安全有效地改善身体成分和 成年人的心肺适应性，更少的研究调查了HIIT在儿童中的作用 青少年，特别是在使用严格的研究设计的全面肥胖治疗的背景下。 结果，本申请提议进行一项飞行员随机对照试验以确定可行性 以及在既定生活方式中整合两种不同的运动训练方法的初步疗效 青少年肥胖的干预。具体而言，有56名青少年，年龄12-16岁，肥胖参与 12周的生活方式干预将随机分配参加两个运动训练课程之一 条件：1）高强度间隔训练（HIIT）或2）连续的，中等强度的训练（CMIT）。两个都 锻炼计划将包括每周三个监督会议。此外，所有青少年都将参加 在针对特定饮食目标并促进自我监控的每周行为体重管理课程中 行为。评估将在基线，干预后（12周）和1个月的随访中完成（16 周）。研究结果将用于1）确定HIIT和CMIT的可行性和可接受性 肥胖青少年的全面生活方式干预； 2）研究HIIT的初步疗效， 与能量匹配的CMIT相比，在青少年肥胖，心肺适应性和心脏代谢 风险因素； 3）探索运动训练条件（HIIT或CMIT）是否影响短期PA水平和 生活方式干预完成后的体重维持。这些初步调查的结果将 通知一项全功能试验，以检查HIIT在青少年肥胖的全面治疗中的作用。