Lifespan Psychosocial Profiles and Biological Pathways to Bone Strength

寿命心理社会概况和骨强度的生物途径

基本信息

批准号：
8318611
负责人：
CAROLYN JANET CRANDALL
金额：
$ 26.35万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-15 至 2014-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8318611
关键词：
Adopted Adoption Adult Affect Age Aging Anxiety Biological Biological Markers Biological Markers Biology Body Size Bone Density Bone Resorption Bone remodeling Child Childhood Chronic Clinical Research Cohort Studies Communities Complement Data Data Analyses Data Collection Elderly Endocrine Epidemiology Equilibrium Fracture Friends Future Goals Growth Happiness Health Human Development Incidence Inflammation Inflammatory Intervention Length Life Life Cycle Stages Life Experience Longevity Maintenance Measurement Measures Mediating Mediator of activation protein Menopause Mental Depression Mental Health Metabolic Metric Modeling Osteogenesis Osteoporosis Outcome Parents Pathway interactions Personal Satisfaction Physiological Psychological Factors Psychology Psychosocial Assessment and Care Psychosocial Factor Psychosocial Influences Public Health Quality of life Recording of previous events Relative (related person)Research Research Design Risk Role Sampling Scientist Screening procedure Serum Social status Socioeconomic Status Sociology Spouses System Testing Time United States Wisconsin Woman Work abstracting biological systems bone bone health bone mass bone strength bone stress bone turnover cohort follow-up high risk hypothalamic-pituitary-adrenal axis indexing innovation life history middle age mortality multidisciplinary novel strategies osteoporosis with pathological fracture psychologic psychosocial resilience social socioeconomics young adult

项目摘要

Project Summary/Abstract Bone strength, or the ability to resist fractures, is critically dependent on bone health in young and middle years - the higher the peak bone mass achieved in younger years, the lower the likelihood of developing osteoporosis in later life. We postulate that social and psychological factors over the lifespan affect bone strength by influencing the level of peak strength achieved in young adulthood, the maintenance of bone strength through middle adulthood, and the rate of decline in older ages. Our specific aims are to: Aim 1. Determine the strength of the association between long-term psychosocial profiles and bone strength. Aim 2. Determine the strength of the association between biological system dysregulation and bone strength. Aim 3. Determine the extent to which the putative biological pathways mediate the associations between long- term psychosocial profiles and bone strength. The project will draw on three cohort studies (Midlife in the United States, the Wisconsin Study of Late Life Resilience, and the MacArthur Study of Successful Aging) that together, have data from adults, ages 24 and up, and have 9 or more years of follow up. This project is uniquely optimized to explore this thesis because: 1) In addition to using standard bone mineral density assessments, we will expand bone health outcomes to include comprehensive assessments of bone strength and bone metabolic balance. 2) We will determine the influence not only of social adversity and psychological ill-health but also of social advantage and psychological well-being on bone outcomes. 3) A lifespan perspective will be adopted, wherein long-term psychosocial influences will be used as predictors of adult bone strength. This project will be the first comprehensive attempt to delineate the influences of multiple psychosocial domains over the life course (including early life experiences) on bone strength, and to identify the biological pathways through which these influences are exerted. Its strengths lie in the unmatched breadth, depth, and longitudinal aspect of psychosocial and biological assessments in the 3 cohort studies, the complementary breadth and depth of bone outcomes assessed across the 3 studies, the lengths of follow up, the large range of ages spanned, and the novel approach to the research questions: the adoption of the more appropriate life- history approach to estimating psychosocial influences on bone strength, the equal consideration given to psychosocial advantage and adversity, and the innovative and comprehensive assessment of bone strength, that goes beyond the usual bone density metric of strength.

项目概要/摘要骨骼强度或抵抗骨折的能力很大程度上取决于年轻人和中年人的骨骼健康岁 - 年轻时达到的峰值骨量越高，患骨质疏松症的可能性就越低晚年骨质疏松。我们假设一生中的社会和心理因素会影响骨骼通过影响成年早期达到的峰值力量水平来维持力量，维持骨骼中年时期的力量，以及老年时期的下降速度。我们的具体目标是：目标 1. 确定长期心理社会状况与骨强度之间的关联强度。目标 2. 确定生物系统失调与骨强度之间关联的强度。目标 3. 确定假定的生物途径在多大程度上介导长期术语心理社会概况和骨强度。该项目将利用三项队列研究（美国中年研究、威斯康星州晚年研究）弹性，以及麦克阿瑟成功老龄化研究），共同收集了 24 岁和 24 岁的成年人的数据并有 9 年或更长时间的随访。该项目针对本论文进行了独特的优化，因为：1）除了使用标准骨矿物质密度评估之外，我们还将骨骼健康结果扩展到包括骨强度和骨代谢平衡的综合评估。 2) 我们将确定不仅受到社会逆境和心理健康状况的影响，而且还受到社会优势和心理健康的影响。心理健康对骨骼结果的影响。 3）采用寿命视角，其中长期心理社会影响将被用作成人骨强度的预测因素。该项目将是首次全面尝试描述多种社会心理因素的影响整个生命过程（包括早期生活经历）的各个领域对骨强度的影响，并确定生物这些影响发挥的途径。它的优势在于无与伦比的广度、深度和 3 项队列研究中心理社会和生物评估的纵向方面，互补 3项研究评估的骨结果的广度和深度、随访时间长短、范围大跨越年龄，以及研究问题的新颖方法：采用更合适的生活方式- 评估心理社会对骨强度影响的历史方法，同等考虑心理社会优势和逆境，以及骨强度的创新和全面评估，这超出了通常的骨密度强度指标。