Lifespan Psychosocial Profiles and Biological Pathways to Bone Strength

寿命心理社会概况和骨强度的生物途径

• 批准号: 7728333
• 负责人: CAROLYN JANET CRANDALL
• 金额: $ 40.05万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-15 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7728333
• 关键词: Adopted; Adoption; Adult; Affect; Age; Aging; Anxiety; Biological; Biological Markers; Biological Markers; Biology; Body Size; Bone Density; Bone Resorption; Bone remodeling; Child; Childhood; Chronic; Clinical Research; Cohort Studies; Communities; Complement; Data; Data Analyses; Data Collection; Elderly; Endocrine; Epidemiology; Equilibrium; Fracture; Friends; Future; Goals; Growth; Happiness; Health; Human Development; Incidence; Inflammation; Inflammatory; Intervention; Length; Life; Life Cycle Stages; Life Experience; Longevity; Maintenance; Measurement; Measures; Mediating; Mediator of activation protein; Menopause; Mental Health; Metabolic; Metric; Modeling; Osteogenesis; Osteoporosis; Outcome; Parents; Pathway interactions; Personal Satisfaction; Physiological; Psychological Factors; Psychology; Psychosocial Assessment and Care; Psychosocial Factor; Psychosocial Influences; Public Health; Quality of life; Recording of previous events; Relative (related person); Research; Research Design; Risk; Role; Sampling; Scientist; Screening procedure; Serum; Social status; Socioeconomic Status; Sociology; Spouses; Stress; System; Testing; Time; United States; Well in self; Wisconsin; Woman; Work; biological systems; bone; bone health; bone mass; bone strength; bone turnover; cohort; depression; follow-up; high risk; hypothalamic-pituitary-adrenal axis; indexing; innovation; life history; middle age; mortality; multidisciplinary; novel strategies; osteoporosis with pathological fracture; psychologic; psychosocial; public health relevance; resilience; social; socioeconomics

DESCRIPTION (provided by applicant): Bone strength, or the ability to resist fractures, is critically dependent on bone health in young and middle years - the higher the peak bone mass achieved in younger years, the lower the likelihood of developing osteoporosis in later life. We postulate that social and psychological factors over the lifespan affect bone strength by influencing the level of peak strength achieved in young adulthood, the maintenance of bone strength through middle adulthood, and the rate of decline in older ages. Our specific aims are to: Aim 1. Determine the strength of the association between long-term psychosocial profiles and bone strength. Aim 2. Determine the strength of the association between biological system dysregulation and bone strength. Aim 3. Determine the extent to which the putative biological pathways mediate the associations between long- term psychosocial profiles and bone strength. The project will draw on three cohort studies (Midlife in the United States, the Wisconsin Study of Late Life Resilience, and the MacArthur Study of Successful Aging) that together, have data from adults, ages 24 and up, and have 9 or more years of follow up. This project is uniquely optimized to explore this thesis because: 1) In addition to using standard bone mineral density assessments, we will expand bone health outcomes to include comprehensive assessments of bone strength and bone metabolic balance. 2) We will determine the influence not only of social adversity and psychological ill-health but also of social advantage and psychological well-being on bone outcomes. 3) A lifespan perspective will be adopted, wherein long-term psychosocial influences will be used as predictors of adult bone strength. This project will be the first comprehensive attempt to delineate the influences of multiple psychosocial domains over the life course (including early life experiences) on bone strength, and to identify the biological pathways through which these influences are exerted. Its strengths lie in the unmatched breadth, depth, and longitudinal aspect of psychosocial and biological assessments in the 3 cohort studies, the complementary breadth and depth of bone outcomes assessed across the 3 studies, the lengths of follow up, the large range of ages spanned, and the novel approach to the research questions: the adoption of the more appropriate life- history approach to estimating psychosocial influences on bone strength, the equal consideration given to psychosocial advantage and adversity, and the innovative and comprehensive assessment of bone strength, that goes beyond the usual bone density metric of strength. PUBLIC HEALTH RELEVANCE: This project will determine how bone strength (i.e., bone's ability to resist fracture) is affected by life histories of socioeconomic status (financial condition and social status), social relationships (with parents, spouse, friends, children, etc.), and psychological health (both positive aspects such as happiness, life satisfaction, personal growth and purpose in life, and negative ones, such as depression and anxiety). We will also examine which biological changes might explain these social and psychological effects on bone health. Discovery of these effects on bone strength and the biological mechanisms will mean that we can identify and target those at high risk for fractures for early screening and interventions, with the eventual goal of reducing the burden of osteoporosis (low bone strength) on quality of life and mortality.

描述（由申请人提供）：骨强度或抵抗骨折的能力很大程度上取决于年轻和中年的骨骼健康 - 年轻时达到的峰值骨量越高，晚年患骨质疏松症的可能性就越低。我们假设一生中的社会和心理因素通过影响青年期达到的峰值强度水平、中年时期骨强度的维持以及老年时期的骨强度下降率来影响骨强度。我们的具体目标是： 目标 1. 确定长期社会心理特征与骨强度之间关联的强度。目标 2. 确定生物系统失调与骨强度之间关联的强度。目标 3. 确定假定的生物学途径在多大程度上介导长期社会心理特征和骨强度之间的关联。该项目将借鉴三项队列研究（美国中年、威斯康星州晚年复原力研究和麦克阿瑟成功老龄化研究），这些研究的数据来自 24 岁及以上且有 9 年或以上生活经历的成年人的跟进。该项目针对本论文进行了独特的优化，因为：1）除了使用标准骨矿物质密度评估之外，我们还将扩展骨骼健康结果，包括骨强度和骨代谢平衡的综合评估。 2）我们不仅要确定社会逆境和心理健康状况，还要确定社会优势和心理健康对骨骼结果的影响。 3）将采用寿命视角，其中长期心理社会影响将被用作成人骨强度的预测因子。该项目将是首次全面尝试描述生命历程中多个社会心理领域（包括早期生活经历）对骨骼强度的影响，并确定这些影响发挥作用的生物学途径。其优势在于 3 项队列研究中心理社会和生物学评估的广度、深度和纵向方面无与伦比，3 项研究中评估的骨骼结果的广度和深度互补，随访时间长，年龄跨度大以及研究问题的新颖方法：采用更合适的生活史方法来估计社会心理对骨强度的影响，平等考虑社会心理的优势和逆境，以及创新和全面的骨强度评估，超出了通常的骨密度强度指标。公共健康相关性：该项目将确定社会经济地位（财务状况和社会地位）、社会关系（与父母、配偶、朋友、孩子等的生活史）如何影响骨骼强度（即骨骼抵抗骨折的能力）。 ）和心理健康（包括积极的方面，如幸福、生活满意度、个人成长和人生目标，以及消极的方面，如抑郁和焦虑）。我们还将研究哪些生物学变化可以解释这些社会和心理对骨骼健康的影响。发现这些对骨强度的影响和生物学机制将意味着我们可以识别和针对骨折高危人群进行早期筛查和干预，最终目标是减轻骨质疏松症（骨强度低）对生活质量的负担和死亡率。