Sickle Cell Reproductive CHOICES: Efficacy of a Primary Prevention Intervention

镰状细胞生殖选择：一级预防干预措施的功效

• 批准号: 8320681
• 负责人: Agatha M. Gallo
• 金额: $ 60.91万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-02-15 至 2015-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8320681
• 关键词: African American; Attention; Award; Basic Science; Behavior; Chicago; Communities; Community Healthcare; Consultations; Education; Effectiveness; Fostering; Funding; Genetic; Goals; Health behavior; Infant; Internet; Intervention; Interview; Knowledge; Longitudinal Studies; Measures; Methods; Morbidity - disease rate; Multimedia; National Heart, Lung, and Blood Institute; Neonatal Screening; Online Systems; Outcome; Parenting behavior; Parents; Participant; Penicillins; Pregnancy; Preventive Intervention; Primary Prevention; Procedures; Program Reviews; Publishing; Questionnaires; Randomized; Recruitment Activity; Reproductive Behavior; Reproductive Health; Research; Sampling; Schedule; Sickle Cell; Sickle Cell Anemia; Sickle Cell Trait; Site; Specific qualifier value; Testing; Time; Translational Research; United States; Vaccination; base; design; early childhood; efficacy trial; experience; follow-up; innovation; member; mortality; programs; prophylactic; reproductive; theories; transmission process; treatment as usual; young adult; young man; young woman

DESCRIPTION (provided by applicant): Our long-term goal is to foster informed reproductive health decisions by young adults with sickle cell disease (SCD) or sickle cell trait (SCT). Unfortunately for many young adults with SCD and SCT pregnancies occur without the opportunity to make well-informed reproductive health decisions, which is related to insufficient or incorrect knowledge of one's or the partner's SCD/SCT status or its genetic transmission. We will determine the long-term 12-, 18- and 24-mo effects on reproductive knowledge and reproductive health behaviors in a two-group design with CHOICES or usual care attention control [eBook] interventions. In this mixed-method application we will complete the efficacy trial, add a new qualitative aim at 24 mos to understand how study participation influenced participants' reproductive behaviors, and with a National Advisory Board (NAB), plan and pilot test the feasibility of a multi-site web-based study in 4 states (CA, TX, NC, CT). Specific aims are to: Aim 1. In 236 young adults (18 to 35 yr) with SCD or SCT, compare usual care and CHOICES boosted (at 12 mos) groups for sustained effects on reproductive health knowledge and reproductive health behaviors (at 12, 18, & 24 mo). At all time points, we hypothesize that knowledge scores and behaviors consistent with the parenting plan will be greater in the CHOICES group than the usual care group. Aim 2. From interviews with 60 of these participants, explore their views about and experience with the aim1 study participation and what influenced their reproductive health behaviors during the study. We will identify conditions under which participants did or did not change their reproductive health behaviors as participants in the control or CHOICES groups, which will be important for interpretation of outcomes and if indicated by qualitative findings to modify the intervention(s). Aim 3. In 100 newly recruited young adults (18 to 35 yr) with SCD or SCT, determine the feasibility of replicating the CHOICES trial as a 24-mo multi-site, community-based study with Internet- and web-based recruitment, delivery, and retention strategies. The recruitment and retention rates and NAB consultation will guide design of procedures for a multi-site national effectiveness study of the CHOICES intervention. PUBLIC HEALTH RELEVANCE: Tested in this study is the CHOICES intervention, which was developed with extensive input from the sickle cell community. CHOICES is a new web-based, tailored, multimedia education program about sickle cell disease, reproductive options and consequences that is designed to help young men and women with sickle cell disease or sickle cell trait to implement a parenting plan in advance of pregnancy.

描述（由申请人提供）：我们的长期目标是促进患有镰状细胞病（SCD）或镰状细胞性状（SCT）的年轻人的知情生殖健康决定。不幸的是，对于许多患有SCD和SCT妊娠的年轻人而没有做出明智的生殖健康决定，这与对伴侣或伴侣的SCD/SCT状态或其遗传传播的了解不足或不正确有关。我们将在两组设计中使用选择或通常的护理注意力控制[eBook]干预措施的两组设计中的生殖知识和生殖健康行为的长期效果。在此混合方法应用程序中，我们将完成疗效试验，为24 MOS添加新的定性目标，以了解研究参与如何影响参与者的生殖行为，并通过国家顾问委员会（NAB）（NAB），计划和试点测试，在4个州（CA，TX，NC，CT）进行基于多站点的网络研究的可行性。具体目的是：AIM 1。在236名年轻人（18至35岁）中，使用SCD或SCT进行比较，比较普通的护理和选择（在12个MOS）组中，以持续对生殖健康知识和生殖健康行为的持续影响（12、18，＆24 MO）。在所有时间点，我们假设在选择组中，与育儿计划一致的知识得分和行为将比通常的护理组更大。 AIM 2。从对60名参与者的访谈中，探索他们对AIM1研究参与的看法和经验，以及在研究期间影响其生殖健康行为的原因。我们将确定参与者在控制或选择组中改变其生殖健康行为或不改变其生殖健康行为的条件，这对于解释结果的解释至关重要，如果由定性发现表示，以修改干预措施。 AIM 3。在100名新招募的年轻人（18至35岁）中，使用SCD或SCT确定将选择试验复制为24 MO多站点，基于社区的研究的可行性，该研究具有基于互联网和基于网络的招聘，交付和保留策略。招聘和保留率以及NAB咨询将指导对选择干预的多站点国家有效性研究的程序设计。 公共卫生相关性：在这项研究中进行了测试是选择干预措施，该干预措施是通过镰状细胞社区的广泛投入而开发的。选择是一项新的基于Web的，量身定制的多媒体教育计划，涉及镰状细胞疾病，生殖选择和后果，旨在帮助患有镰状细胞疾病或镰状细胞性状的年轻男女在怀孕之前实施育儿计划。