Targeting Cancer Cells with Functionalized Nanoparticle Libraries

用功能化纳米粒子库靶向癌细胞

• 批准号: 8319439
• 负责人: MATTHEW LEVY
• 金额: $ 17.61万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-12 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8319439
• 关键词: Affinity; Animal Model; Avidity; Binding; Biological; Cancer Diagnostics; Capsid Proteins; Cells; Detection; Development; Diagnostic; Disease; Engineering; Evolution; Generations; Goals; Human; In Vitro; Individual; Lead; Libraries; Ligands; Magnetic Resonance Imaging; Magnetism; Malignant neoplasm of prostate; Methodology; Methods; Microspheres; Modeling; Monitor; Mus; Nucleic Acids; Population; Property; Proteins; Research; Screening for cancer; Serum; Signal Transduction; Surface; System; Techniques; Technology; Testing; Therapeutic; Therapeutic Human Experimentation; Time; Virus; Work; Xenograft procedure; aptamer; base; cancer cell; cancer therapy; nanoparticle; novel; particle; tissue culture; tumor; tumor xenograft

DESCRIPTION (provided by applicant): We propose to use a combination of two powerful techniques: aptamer selection (systematic evolution of ligands by exponential enrichment; SELEX) and in vitro compartmentalization (IVC), to develop a new method of generating libraries of functionalized nanoparticles and that can be screened directly for function. While the goal of this application is to develop a novel system for the direct identification of targeted nanoparticles which localize to human tumors, we will develop a platform technology which extends beyond the detection and treatment of cancer and other diseases and will result in the generation of a novel class of capture agents that will find use in a variety of applications and fields of research.

描述（由申请人提供）：我们建议结合使用两种强大的技术：适体选择（通过指数富集进行配体的系统进化；SELEX）和体外区室化（IVC），以开发一种生成功能化纳米粒子库的新方法并且可以直接筛选其功能。虽然该应用的目标是开发一种新的系统来直接识别定位于人类肿瘤的靶向纳米粒子，但我们将开发一种平台技术，其范围超出了癌症和其他疾病的检测和治疗范围，并将导致产生一类新型捕获剂，可用于各种应用和研究领域。