Targeting Cancer Cells with Functionalized Nanoparticle Libraries

用功能化纳米粒子库靶向癌细胞

• 批准号: 8319439
• 负责人: MATTHEW LEVY
• 金额: $ 17.61万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-12 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8319439
• 关键词: Affinity; Animal Model; Avidity; Binding; Biological; Cancer Diagnostics; Capsid Proteins; Cells; Detection; Development; Diagnostic; Disease; Engineering; Evolution; Generations; Goals; Human; In Vitro; Individual; Lead; Libraries; Ligands; Magnetic Resonance Imaging; Magnetism; Malignant neoplasm of prostate; Methodology; Methods; Microspheres; Modeling; Monitor; Mus; Nucleic Acids; Population; Property; Proteins; Research; Screening for cancer; Serum; Signal Transduction; Surface; System; Techniques; Technology; Testing; Therapeutic; Therapeutic Human Experimentation; Time; Virus; Work; Xenograft procedure; aptamer; base; cancer cell; cancer therapy; nanoparticle; novel; particle; tissue culture; tumor; tumor xenograft

DESCRIPTION (provided by applicant): We propose to use a combination of two powerful techniques: aptamer selection (systematic evolution of ligands by exponential enrichment; SELEX) and in vitro compartmentalization (IVC), to develop a new method of generating libraries of functionalized nanoparticles and that can be screened directly for function. While the goal of this application is to develop a novel system for the direct identification of targeted nanoparticles which localize to human tumors, we will develop a platform technology which extends beyond the detection and treatment of cancer and other diseases and will result in the generation of a novel class of capture agents that will find use in a variety of applications and fields of research.

描述（由申请人提供）：我们建议使用两种功能强大的技术的组合：适体选择（通过指数富集对配体进行系统演化； SELEX； SELEX）和体外隔室化（IVC），以开发一种生成功能化纳米杆菌库的新方法，并可以直接筛选出可直接筛选以供函数筛选。尽管该应用的目的是开发一种新型系统，用于直接鉴定定位于人类肿瘤的靶向纳米颗粒，但我们将开发一种平台技术，该技术超出了对癌症和其他疾病的检测和治疗，并将导致一类新型的捕获药物的生成，这些捕获药物将在各种应用和研究领域中发现使用。