ZINC TREATMENT TO REDUCE DURATION OF DIARRHEA

锌治疗可缩短腹泻持续时间

• 批准号: 8172631
• 负责人: MARI S GOLUB
• 金额: $ 7.6万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172631
• 关键词: Acute; Adult; Computer Retrieval of Information on Scientific Projects Database; Diarrhea; Funding; Gastroenteritis; Grant; Human; Hydration status; Infant; Infant Development; Institution; Macaca mulatta; Oral; Population; Recurrence; Research; Research Personnel; Resources; Source; Supplementation; United States National Institutes of Health; Work; Zinc; Zinc deficiency; fetal

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Previous studies at the CNPRC contributed to the understanding of the impact of zinc deficiency on fetal and infant development. Subsequently, zinc supplementation has been widely undertaken internationally in human populations where zinc deficiency is edemic. As a consequence of studies of infants in these populations, an assosciation between zinc supplementation and reduced duration and recurrence of diarrhea was uncovered. In the proposed work, both weanling and adult rhesus macaques identified with acute gastroenteritis and diarrhea would receive oral zinc supplemnts and hydration therapy, which could result in a new treatment for diarrhea in the CNPRC indoor rhesus colony.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 CNPRC 之前的研究有助于了解缺锌对胎儿和婴儿发育的影响。 随后，国际上在缺锌水肿人群中广泛开展补锌工作。 对这些人群中的婴儿进行的研究结果发现，补充锌与腹泻持续时间缩短和复发之间存在关联。 在拟议的工作中，患有急性胃肠炎和腹泻的断奶期和成年恒河猴都将接受口服锌补充剂和水化治疗，这可能会为 CNPRC 室内恒河猴群体的腹泻带来新的治疗方法。