Regenerative Tissue Engineering and Transplantation

再生组织工程与移植

• 批准号: 8256913
• 负责人: James Wavell Aiken
• 金额: $ 1.56万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8256913
• 关键词: Address; Advanced Development; Affect; Basic Science; Biocompatible Materials; Biological; Biological Sciences; Bladder; Cells; Clinical Medicine; Collaborations; Colorado; Communities; Development; Disease; Engineering; Individual; Injury; Knowledge; Medicine; Methodology; Musculoskeletal; Nerve; Organ; Outcome; Participant; Procedures; Regenerative Medicine; Regulation; Request for Proposals; Research; Research Personnel; Scientist; Solid; Stem cells; Structure; Technology; Therapeutic; Tissue Engineering; Tissue Transplantation; Tissues; Training; Translational Research; Transplantation; Trauma; Vision; base; clinical application; clinical practice; experience; functional loss; injured; insight; meetings; novel; organ regeneration; reconstruction; regenerative; regenerative therapy; repaired; scaffold; stem; symposium; tissue regeneration; tool

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled Regenerative Tissue Engineering and Transplantation, organized by Rocky S. Tuan, Farshid Guilak and Anthony Atala, which will be held in Breckenridge, Colorado from April 1 - 6, 2012. Tissue engineering and regenerative medicine is a dynamic, translational research field that amalgamates life sciences, engineering, and clinical medicine for the purpose of restoring structure and function to diseased, damaged or injured tissues and organs. Current efforts focus on the application of stem and progenitor cells, bioactive factors and biomaterial scaffolds in transplantation procedures to affect regenerative therapies. Breakthroughs in bladder and tracheal reconstruction and highly promising approaches for solid organ regeneration as well as musculoskeletal and nerve repair have been achieved. Effective cell sourcing, optimal assembly and fabrication of tissue-derived and synthetic biomaterial scaffolds, and targeted regulation of therapeutic and immunomodulatory functions of stem cells represent some of the current challenges in this field. In this Keystone Symposia meeting on Regenerative Tissue Engineering and Transplantation, exciting technological and intellectual advances in the field will be synthesized by expert scientists, engineers, and clinicians to assess and expand the landscape in regenerative engineering and transplantation. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Mechanisms of Whole Organ Regeneration, which will share an opening and closing keynote address as well as two plenary sessions with this meeting. More specifically, the pairing of these 2 meetings represents a highly unusual opportunity for crosstalk between the more applications-driven field of tissue engineering and regenerative medicine, and the very basic research being explored in the field of whole organ regeneration. PUBLIC HEALTH RELEVANCE: Structural and functional loss of tissues and organs through disease, injury, and trauma is a significant challenge in medicine. Development of advanced regenerative and transplantation technologies is of essential benefit to these affected individuals. The Keystone Symposia meeting on Regenerative Tissue Engineering and Transplantation will directly address challenges in this field. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Mechanisms of Whole Organ Regeneration, which will share an opening and closing keynote address as well as two plenary sessions with this meeting.

描述（由申请人提供）：本提案请求支持题为“再生组织工程与移植”的 Keystone 研讨会，该会议由 Rocky S. Tuan、Farshid Guilak 和 Anthony Atala 组织，将于 4 月 1 日至 6 日在科罗拉多州布雷肯里奇举行， 2012. 组织工程和再生医学是一个动态的转化研究领域，融合了生命科学、工程和临床医学，旨在恢复组织的结构和功能患病、受损或受伤的组织和器官。目前的工作重点是在移植过程中应用干细胞和祖细胞、生物活性因子和生物材料支架来影响再生疗法。膀胱和气管重建方面取得了突破，实体器官再生以及肌肉骨骼和神经修复的方法也很有前景。有效的细胞来源、组织源性和合成生物材料支架的最佳组装和制造以及干细胞治疗和免疫调节功能的针对性调节是该领域当前面临的一些挑战。在本次关于再生组织工程和移植的 Keystone 研讨会上，专家科学家、工程师和临床医生将综合该领域令人兴奋的技术和知识进步，以评估和扩大再生工程和移植的前景。同期举行的全器官再生机制会议将大大增加跨学科互动的机会，该会议将与本次会议分享开幕和闭幕主题演讲以及两场全体会议。更具体地说，这两次会议的配对代表了一个非常不寻常的机会，可以在更多应用驱动的组织工程和再生医学领域与整个器官再生领域正在探索的基础研究之间进行交流。 公共卫生相关性：疾病、损伤和创伤导致的组织和器官的结构和功能丧失是医学上的重大挑战。先进的再生和移植技术的发展对这些受影响的个体至关重要。关于再生组织工程和移植的 Keystone 研讨会将直接解决该领域的挑战。同期举行的全器官再生机制会议将大大增加跨学科互动的机会，该会议将与本次会议分享开幕和闭幕主题演讲以及两场全体会议。