Multiple Sclerosis

多发性硬化症

基本信息

批准号：
8391042
负责人：
James Wavell Aiken
金额：
$ 0.8万
依托单位：
KEYSTONE SYMPOSIA
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-01-01 至 2013-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8391042
关键词：
Academia Adopted Advocacy Advocate Affect Agreement Area Autoimmune Diseases Autoimmunity Biomedical Engineering Chronic Disease Client Clinical Clinical Research Complement Complex Degenerative Disorder Development Disease Disease Outcome Drug Industry Elements Epidemiology Epigenetic Process Foundations Future Genetic Genomics Heterogeneity Immune system Immunotherapy Industry Left Link Lipids Measures Medicine Mind Molecular Montana Movement Multiple Sclerosis Myelin Nanotechnology Nature Nerve Degeneration Neurodegenerative Disorders Neurologic Neurons Oral Outcome Participant Pathogenesis Patient Care Patients Play Regenerative Medicine Research Research Personnel Scientist Seeds Severity of illness Stratification Systems Biology Technology Therapeutic Therapeutic Intervention Time Translational Research base bodily sensation burden of illness cellular engineering disability genome wide association study holistic approach human disease knowledge base meetings neglect novel novel strategies programs regenerative research and development stem cell biology symposium

项目摘要

DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled Multiple Sclerosis, organized by Trevor J. Kilpatrick, Brenda Banwell and Hartmut Wekerle. The meeting will be held in Big Sky, Montana from January 11 - 16, 2013. Multiple sclerosis (MS) is a complex disease in which genetic, environmental and stochastic factors all play a part to induce aberrant interactions between the immune system and neural cells, ultimately transforming into progressive neurological disability. Our understanding of MS is rapidly evolving and multiple areas of research are showing great promise of future treatment or cure. However, further progress will depend on establishing a deep understanding of the underlying disease mechanisms. With this in mind, this meeting aims to: 1) define integrated approaches by which to study disease pathogenesis, which represents a critical barrier to progress in the field; 2) provide an up to date perspective on molecular pathogenesis and how this might be used to optimize patient management; 3) define state of the art technologies by which to quantitate disease burden; 4) discuss key elements concerning the concept of disease heterogeneity and how emergent approaches to disease stratification can optimize management strategies; and 5) provide perspectives concerning the potential therapeutic applications of neuroprotective, regenerative and bioengineering based strategies, and how these might complement immunotherapy. Speakers have been carefully selected on the basis that, independent of whether they are basic scientists or clinician researchers, they each have a track record in adopting a multi-disciplinary approach that has enabled the application of discoveries in one area of endeavor to seed advances in another. We anticipate that participants will gain an understanding of how a systems biology based approach can accelerate our knowledge base of multiple sclerosis and how that knowledge base can be successfully applied to novel clinical research and development, as well as potentiated patient care.

描述（由申请人提供）：请求支持题为“多发性硬化症”的 Keystone 研讨会，该会议由 Trevor J. Kilpatrick、Brenda Banwell 和 Hartmut Wekerle 组织。会议将于 2013 年 1 月 11 日至 16 日在蒙大拿州 Big Sky 举行。多发性硬化症 (MS) 是一种复杂的疾病，其中遗传、环境和随机因素都起作用，导致免疫系统和神经细胞之间的异常相互作用。，最终转化为进行性神经功能障碍。我们对MS的理解是快速发展的多个研究领域显示出未来治疗或治愈的巨大前景。然而，进一步的进展将取决于对潜在疾病机制的深入了解。考虑到这一点，本次会议的目的是：1）定义研究疾病发病机制的综合方法，这是该领域进展的一个关键障碍； 2）提供分子发病机制的最新观点以及如何利用它来优化患者管理； 3) 定义用于量化疾病负担的最先进技术； 4）讨论有关疾病异质性概念的关键要素以及疾病分层的新兴方法如何优化管理策略； 5) 提供有关基于神经保护、再生和生物工程的策略的潜在治疗应用的观点，以及这些策略如何补充免疫疗法。演讲者都是经过精心挑选的，因为无论他们是基础科学家还是临床研究人员，他们每个人都有采用多学科方法的记录，这种方法能够将发现应用到一个努力领域，从而推动未来的进步。其他。我们预计参与者将了解基于系统生物学的方法如何加速我们的多发性硬化症知识库，以及如何将该知识库成功应用于新型临床研究和开发以及加强患者护理。