The Role of Vascular Aging in Cognitive and Physical Function

血管老化在认知和身体功能中的作用

• 批准号: 8372161
• 负责人: Lydia Bazzano
• 金额: $ 61.68万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8372161
• 关键词: Adolescence; Adult; Age; Aging; Aging-Related Process; Birth; Birth Weight; Blood Vessels; Cardiac; Childhood; Clinical; Cognition; Cognitive; Cohort Studies; Data; Development; Disease; Disease Marker; Early treatment; Elderly; Epidemiologic Studies; Female; Gender; Gestational Age; Health; Health Care Costs; Heart; Impaired cognition; Incidence; Individual; Intervention; Investments; Life; Linear Models; Link; Longevity; Low Birth Weight Infant; Maintenance; Measures; Mediating; Microcirculation; Morbidity - disease rate; Participant; Performance; Persons; Physical Function; Play; Population; Race; Recruitment Activity; Research; Resources; Risk; Risk Factors; Role; Rural Community; Socioeconomic Factors; Structure; Testing; Time; Vascular Diseases; Vascular System; Woman; age related; cardiovascular risk factor; cognitive function; cohort; disorder risk; healthy aging; heart dimension/size; improved; longitudinal analysis; male; men; middle age; mortality; novel

DESCRIPTION (provided by applicant): Maintaining optimal health, both physical and cognitive, throughout the aging process is critical to minimizing healthcare costs and morbidity and mortality associated with diseases of aging. The integrity of the vascular system is essential for healthy aging. Aging-related structural and functional disturbances in the macro- or microcirculation contribute the development of cognitive dysfunction and declining physical performance. Early life factors, from birth through childhood and adolescence, may play an important role in successful cognitive and physical aging via the aging of the vascular system. In the proposed study we will examine the role of vascular aging in maintenance of cognitive and physical performance by recruiting 1,257 participants in the Bogalusa Heart Study cohort who participated in cardiovascular risk factors examinations at least twice in childhood and twice again in adulthood. Participants will undergo cognitive function testing, physical function assessments and vascular risk factor examination with noninvasive studies of vascular structure and function. Birth weight and childhood socioeconomic and risk factor data is available for all individuals. Longitudinal analysis will be used to examine the relationship of early life risk factrs to subclinical vascular disease markers, while linear models will be used to examine the role of vascular risk factors and subclinical markers in maintenance of cognitive and physical function. This study represents a unique opportunity because all vascular disease risk factors have been collected prospectively from early life to middle-age in this bi-racial (black/white), rural community, allowing for exploration of race and gender relationships with cognitive and physical function from mid-life. The proposed research will link vascular risk factors across the life span and subclinical vascular markers in early middle age with cognitive and physical performance in later middle age. In doing so, we will identify risk factors, timing and subpopulations for intervention that could reduce the incidence of cognitive and physical decline in old age and improve the rate of successful aging for persons across the nation. PUBLIC HEALTH RELEVANCE: The proposed research will link vascular risk factors across the life span and subclinical vascular measures in early middle age with cognitive and physical performance in later middle age. In doing so, we will identify risk factors, timing and subpopulations for intervention that could reduce the incidence of cognitive and physical decline in old age and improve the rate of successful aging for persons across the nation.

描述（由申请人提供）：在整个衰老过程中，保持最佳健康，无论是身体和认知，对于最大程度地减少与衰老疾病相关的医疗保健成本以及发病率和死亡率至关重要。血管系统的完整性对于健康衰老至关重要。宏观或微循环中与衰老相关的结构和功能障碍会导致认知功能障碍和身体性能下降。从出生到童年和青春期，早期的生命因素可能会通过血管系统的衰老成功地认知和身体衰老起重要作用。在拟议的研究中，我们将通过招募Bogalusa心脏研究队列中的1,257名参与者来研究血管衰老在维持认知和身体性能方面的作用，他们参加了心血管危险因素检查，至少在儿童时期至少两次，并在成年期间再次参加了两次。参与者将接受认知功能测试，身体功能评估和血管风险因素检查，并通过对血管结构和功能的无创研究。所有个人都可以使用出生体重和儿童社会经济和危险因素数据。纵向分析将用于检查早期生命风险FACTR与亚临床血管疾病标志物的关系，而线性模型将用于检查血管危险因素和亚临床标记在维持认知和身体功能方面的作用。这项研究是一个独特的机会来自中年。拟议的研究将在中年早期的整个生命周期和亚临床血管标记中与中期早期的认知和身体表现联系起来。在此过程中，我们将确定干预措施的危险因素，时机和亚群，以减少老年认知和身体下降的发生率，并提高全国人的成功衰老率。 公共卫生相关性：拟议的研究将在中期早期的生命周期和亚临床血管措施中与中期早期的认知和身体性能联系起来。在此过程中，我们将确定干预措施的危险因素，时机和亚群，以减少老年认知和身体下降的发生率，并提高全国人的成功衰老率。