7th International Conference on Fe-S Cluster Biogenesis and Regulation

第七届铁硫簇生物发生与调控国际会议

• 批准号: 8529798
• 负责人: Franklin Wayne Outten
• 金额: $ 0.4万
• 依托单位: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8529798
• 关键词: Animal Model; Applied Research; Basic Science; Biochemistry; Biogenesis; Biology; Cells; Chemistry; Clinical; Clinical Sciences; Collaborations; Communities; Complex; Defect; Development; Disabled Persons; Discipline; Disease; Electron Transport; Enzymatic Biochemistry; Enzymes; Exposure to; Fertilization; Fostering; Friedreich Ataxia; Funding; Health; Hereditary Disease; Human; Human Genetics; International; Iron; Lead; Life; Link; Medical; Mentors; Metabolic; Metabolism; Metalloproteins; Metals; Molecular; Molecular Biology; Molecular Chaperones; Myopathy; Nitrogen; Nitrogenase; Oral; Organism; Oxygen; Participant; Pathology; Phylogenetic Analysis; Physicians; Play; Process; Protein S; Proteins; Recruitment Activity; Regulation; Request for Proposals; Research; Research Personnel; Role; Scientific Advances and Accomplishments; Scientist; Series; Sideroblastic Anemia; South Carolina; Spectrum Analysis; Sulfides; Sulfur; Sum; System; Underrepresented Minority; Universities; Woman; Work; abstracting; career; cofactor; human disease; insight; iron metabolism; meetings; metalloenzyme; metalloregulatory protein; microcytic anemia; mitochondrial dysfunction; posters; public health relevance; response; scaffold; sensor; success; symposium; trafficking

DESCRIPTION (provided by applicant): The 7th International Conference on Fe-S Cluster Biogenesis and Regulation will take place in Columbia, South Carolina from May 20 - 24, 2013. This conference is the latest in a biennial series of conferences on Fe-S cluster biogenesis and metabolism that has become the principal meeting for a diverse group of researchers in this rapidly expanding field. Iron-sulfur (Fe-S) clusters are used as cofactors by proteins for myriad functions within the cell, ranging from electron transfer and substrate activation in metalloenzymes to reactive oxygen and nitrogen sensors in metalloregulatory proteins. Fe-S clusters are assembled in cells in response to changes in metabolic demand and environmental conditions using a complex network of proteins that carry out iron and sulfur mobilization, de novo cluster assembly, and trafficking of clusters to target metalloproteins. A particular strength of this conference has been its ability to bring together scientists focused on understanding the molecular details of Fe-S protein maturation and scientists/medical doctors studying the direct impact of Fe-S cluster metabolism on human health. Over the last decade it has become clear that disruption of Fe-S cluster formation and delivery can lead to a variety of human diseases such as Friedreich¿s ataxia, X-linked sideroblastic anemia, sideroblastic-like microcytic anemia, and various myopathies and mitochondrial dysfunction disorders. This meeting promotes integrated discussion of the fundamental biochemistry and molecular biology of Fe-S cluster biogenesis to help define the pathology of human diseases associated with dysregulation of iron metabolism. Currently there is no other meeting series that accomplishes this important task.

描述（由适用提供）：第七届FE-S聚集生物发生和调节的国际会议将于2013年5月20日至24日在南卡罗来纳州哥伦比亚举行。这次会议是针对Fe-S Cluster Biogenesis和代谢的一系列大约一系列会议的最新会议。铁硫（Fe-S）簇被蛋白质用作蛋白质的辅助因子，用于细胞内的众多功能，从金属酶中的电子转移和底物激活到金属测量蛋白中的活性氧和氮传感器。 Fe-S簇使用复杂的蛋白质网络响应代谢需求和环境条件的变化，使用复杂的蛋白质网络，这些蛋白质进行了铁和硫动员，从头簇组装，以及将簇转移到靶标金属蛋白上。特殊的力量 本次会议的能力是将专注于了解Fe-S蛋白成熟的分子细节以及研究FE-S群集代谢对人类健康的直接影响的科学家的能力。在过去的十年中，很明显，Fe-S簇的形成和传递的破坏会导致各种人类疾病，例如Friedreich s axaxia，X连锁的Sideroblastic贫血，副细胞样的微细胞性贫血，各种肌瘤病，以及各种肌瘤性和线粒体功能障碍分散。这次会议促进了Fe-S聚集生物发生的基本生物化学和分子生物学的综合讨论，以帮助定义与铁代谢失调相关的人类疾病的病理。当前，没有其他会议系列可以完成这项重要任务。