PROJECT B

项目B

• 批准号: 8277484
• 负责人: Petko M Petkov
• 金额: $ 45.46万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8277484
• 关键词: Address; Biological Process; Chromosomes; DNA; Data; Epistatic Gene; Event; Genes; Genetic; Genetic Recombination; Genetic Variation; Genome; Goals; Grant; Knowledge; Location; Maps; Meiotic Recombination; Mus; Organism; Pattern; Population Genetics; Positioning Attribute; Regulation; Sampling; Silicon Dioxide; System; Wisconsin; Work; genetic evolution

Project B: Systems Genetics of Meiotic Recombination; Petko Petkov, Kenneth Paigen (Jackson), Karl Broman (U Wisconsin-Madison) Meiotic recombination is a fundamental biological process required by all sexually reproducing organisms. The placement of recombination events determines inheritance of allelic combinations which is of importance in population genetics and evolution. In our previous work we have identified recombination hotspots whose pattern of activity requires combined action of epistatic regulators. The goal of this project is to identify epistatic genes that interact in networks to control the location and activity of recombination hotspots.

项目B：减数​​分裂重组的系统遗传学；佩特科·佩特科夫、肯尼思·佩根（杰克逊）、卡尔 布罗曼（威斯康星大学麦迪逊分校） 减数分裂重组是所有有性生殖生物体所需的基本生物过程。这 重组事件的位置决定了等位基因组合的遗传，这对于 群体遗传学和进化。在我们之前的工作中，我们已经确定了重组热点，其 活动模式需要上位调节剂的联合作用。该项目的目标是识别上位性 在网络中相互作用以控制重组热点的位置和活动的基因。