ANALYSIS OF THE ORB6 KINASE-ASSOCIATED PROTEIN COMPLEX

ORB6 激酶相关蛋白复合物的分析

• 批准号: 8365851
• 负责人: FULVIA VERDE
• 金额: $ 1.28万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8365851
• 关键词: Biology; Cell Proliferation; Cells; Cellular Morphology; Fission Yeast; Funding; Fungal Genome; Grant; Growth; Homologous Gene; Human; Link; Mammalian Cell; National Center for Research Resources; Organism; Phosphotransferases; Principal Investigator; Regulation; Research; Research Infrastructure; Resources; Role; Signal Pathway; Source; United States National Institutes of Health; cost; insight; novel; protein complex; tumor progression

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. In mammalian cells, altered expression or regulation of the conserved kinase NDR has been linked to cancer progression. At the moment there is very limited information on NDR kinase effectors. In fission yeast, the NDR homologue Orb6 has a clear role in the control of cell morphology and proliferation. The identification of novel Orb6-interacting factors will provide insight into the function of a conserved signaling pathway that has a role in growth control in many organisms, including human cells.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 在哺乳动物细胞中，保守激酶NDR的表达或调节改变与癌症的进展有关。 目前，关于NDR激酶效应子的信息非常有限。在裂变酵母中，NDR同源物ORB6在控制细胞形态和增殖中具有明显的作用。新型ORB6相互作用因子的鉴定将洞悉保守信号通路的功能，该途径在包括人类细胞在内的许多生物中具有生长控制中具有作用。