ANALYSIS OF THE ORB6 KINASE-ASSOCIATED PROTEIN COMPLEX

ORB6 激酶相关蛋白复合物的分析

• 批准号: 7602171
• 负责人: FULVIA VERDE
• 金额: $ 0.62万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7602171
• 关键词: Cells; Cellular Morphology; Complex; Computer Retrieval of Information on Scientific Projects Database; Fission Yeast; Funding; Grant; Growth; Homologous Gene; Human; Institution; Link; Mammalian Cell; Organism; Phosphotransferases; Proteins; Regulation; Research; Research Personnel; Resources; Role; Signal Pathway; Source; United States National Institutes of Health; insight; novel; tumor progression

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In mammalian cells, altered expression or regulation of the conserved kinase NDR has been linked to cancer progression. At the moment there is very limited information on NDR kinase effectors. In fission yeast, the NDR homologue Orb6 has a clear role in the control of cell morphology and proliferation. The identification of novel Orb6-interacting factors will provide insight into the function of a conserved signaling pathway that has a role in growth control in many organisms, including human cells.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 在哺乳动物细胞中，保守激酶NDR的表达或调节改变与癌症的进展有关。 目前，关于NDR激酶效应子的信息非常有限。在裂变酵母中，NDR同源物ORB6在控制细胞形态和增殖中具有明显的作用。新型ORB6相互作用因子的鉴定将洞悉保守信号通路的功能，该途径在包括人类细胞在内的许多生物中具有生长控制中具有作用。