MULTIMODAL MPET & MMRI IMAGING INSTRUMENTATION

多式联运 MPET

• 批准号: 8363434
• 负责人: RUSSELL E JACOBS
• 金额: $ 1.01万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363434
• 关键词: Animal Model; Animals; Biological Models; Biological Process; Brain Mapping; Cardiac; Central Nervous System Neoplasms; Complex; Data; Data Collection; Elements; Fiber Optics; Functional Magnetic Resonance Imaging; Funding; Grant; Image; Label; Magnetic Resonance Imaging; Metabolism; Modeling; National Center for Research Resources; Performance; Positron-Emission Tomography; Principal Investigator; Research; Research Infrastructure; Resolution; Resources; Scanning; Scheme; Sensory Receptors; Signal Transduction; Slice; Source; Specimen; System; Technology; Testing; Time; United States National Institutes of Health; Validation; Work; attenuation; computational anatomy; cost; design; detector; drug distribution; imaging modality; imaging probe; improved; in vivo; instrument; instrumentation; neoplastic cell; prototype

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We propose to combine the best features of Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) modalities in a single instrument that will simultaneously record data in both imaging modalities. Moreover, we will develop labeled probes that can be detected in both PET and MRI to aid in the interpretation of complex biological processes. This system will be dedicated to the study of small animal model systems at the highest spatial and temporal resolutions attainable. We will build a high resolution, relatively high sensitivity multi-slice muPET scanner integrated within a customized 7T/30cm small animal MR system that will simultaneously record MR and PET images Through the use of fiber-optic couplings, the muPET system will interfere minimally with the muMR system, enabling high quality muPET and IJMRI data to be acquired essentially simultaneously and in near-perfect spatial registration. This system is a natural extension of earlier proof-of-principle systems and a newer prototype animal muPET system now nearing completion. The basic design elements of the system have been tested and demonstrated to work. The combined system we propose adds a number of important features to improve performance and ease of use for in vivo imaging studies. It also incorporates, for the first time, a multi-slice muPET system, with four detector rings simultaneously providing seven imaging planes, spanning an axial field of view of approximately 8mm, with at least 2mm resolution. Simultaneous muPET/muMRI recordings will provide important correlations not available from temporally and spatially separate scans (e.g. BOLD MRI compared with FDG PET). The melded system will provide high resolution anatomical reference systems for muPET studies The 'in register' muMR images will be used to compute scatter and attenuation in the IJPET images and to estimate partial volume errors in the PET scans, thus aiding quantification of the PET signal. This system will open up a number of opportunities not possible with current independent technologies Among them are: Time correlated IJPET and MRS studies of drug distributions; cardiac, CNS and tumor cell metabolism. Simultaneous fMRI and muPET neuroreceptor brain mapping studies in small animals. Validation of new MRI probes using their PET counterparts. Dual PET/MRI labels will allow for "zooming-in" the MRI data collection scheme to those regions of the specimen containing the label, as well as providing for precise registration of the PET & MR images.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 我们建议将正电子发射断层扫描（PET）和磁共振成像（MRI）模态的最佳特征结合在单个仪器中，该仪器将同时记录两种成像方式中的数据。此外，我们将开发标记的探针，可以在PET和MRI中检测到，以帮助解释复杂的生物学过程。该系统将专门研究以最高的空间和时间分辨率来研究小动物模型系统。我们将建立一个高分辨率，相对较高的敏感性多片Mupet扫描仪，该扫描仪集成在定制的7T/30cm小型动物MR系统中，该系统将通过使用光纤耦合同时记录MR和PET图像，Mupet系统将与MUMR系统的交换很小，并与高质量的ijmri and-ijmri ander insim offers Insimpt and ijmri and ijmri anderiult insimpersimptions system。空间注册。该系统是早期原理验证系统的自然扩展，现在已经完成了更新的原型动物Mupet系统。该系统的基本设计元素已经过测试并证明是有效的。我们提出的组合系统增加了许多重要功能，以提高体内成像研究的性能和易用性。它还首次合并了一个多片毫米系统，其中四个检测器环同时提供了七个成像平面，跨越了大约8mm的轴向视野，并至少分辨率分辨率为2mm。同时mupet/mumri录音将提供从时间和空间分开的扫描中获得的重要相关性（例如，与FDG PET相比，BOLD MRI）。融合的系统将为Mupet研究提供高分辨率的解剖参考系统，用于计算IJPET图像中的“寄存器” MUMR图像，并估算PET扫描中的部分体积误差，从而有助于PET信号的量化。当前的独立技术中，该系统将开辟许多机会：时间相关的IJPET和MRS对药物分布的研究；心脏，中枢神经系统和肿瘤细胞代谢。同时在小动物中同时fMRI和mupet神经受体大脑图研究。使用其宠物对应物对新的MRI探针进行验证。双PET/MRI标签将允许将MRI数据收集方案“缩放”到包含标签的标本的那些区域，并提供PET和MR Images的精确注册。