EFFECT OF DIETARY/ORAL DRUGS ON THE TRACE ELEMENTS IN BREAST CANCER TISSUE

膳食/口服药物对乳腺癌组织中微量元素的影响

• 批准号: 8361311
• 负责人: ANIRUDDHA DEB
• 金额: $ 1.77万
• 依托单位: ILLINOIS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361311
• 关键词: Biophysics; Caliber; Cancer Patient; Fluorescence; Funding; Goals; Grant; HDPE; Infusion procedures; Investigation; Mammary Gland Parenchyma; Measurement; National Center for Research Resources; Oral; Patients; Pharmaceutical Preparations; Principal Investigator; Research; Research Infrastructure; Resources; Sampling; Source; Tissue Sample; Tissues; Trace Elements; United States National Institutes of Health; chemotherapy; cost; design; gemcitabine; malignant breast neoplasm; tumor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The goal of this investigation is to study the changes and their correlation in the trace elements in the histological sections of breast cancer tissues from patients who are on dietary/oral drugs instead of standard chemotherapy (administered by drip or infusion). For the measurement on breast tissues the samples were mounted on specially designed HDPE rings, with an outer diameter of 12 mm and an inner diameter of 6 mm, using kapton tape. This design allowed the x-ray beam to pass through the sample for recording intensity behind the sample as well as fluorescence. We have evaluated the following samples. 1. Breast tissue from normal patient (control sample). 2. Breast tissue from tumor . 3. Breast tissue from tumor cancer patient after administering gemcitabine chemotherapy (tissue collected after 5 days starting from the day gemcitabine was administered), this is mainly because the first signs of change shows after 5 days. 4. Breast tissue from tumor after 15 days of administering gemcitabine. 5. Breast tissue from tumor from administered dietary/oral drug for 22 days. 6. Breast tissue from tumor after 40 days of dietary/oral drug. We are evaluating the results and we expect to complete the set of measurements in 2011 beamtime.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 这项研究的目的是研究来自饮食/口服药物而不是标准化学疗法的患者的乳腺癌组织的痕量元素的变化及其相关性（通过滴水或输注给药）。为了在乳房组织上进行测量，将样品安装在特殊设计的HDPE环上，外径为12毫米，内径为6 mm，使用Kapton胶带为6毫米。 该设计使X射线光束可以通过样品，以记录样品后面的强度以及荧光。我们已经评估了以下样本。 1。正常患者的乳房组织（对照样本）。 2。肿瘤的乳房组织。 3。服用吉西他滨化疗后的肿瘤癌患者的乳腺组织（从吉西他滨进行了5天后收集的组织），这主要是因为5天后出现的变化的第一个迹象。 4。施用吉西他滨15天后，肿瘤的乳房组织。 5。从饮食/口服药物的肿瘤中乳腺组织22天。 6。饮食/口服40天后肿瘤的乳腺组织。 我们正在评估结果，并希望在2011年的Beamtime完成一组测量值。