EFFECT OF DIETARY/ORAL DRUGS ON THE TRACE ELEMENTS IN PANCREATIC CANCER TISSUE

膳食/口服药物对胰腺癌组织中微量元素的影响

• 批准号: 8361314
• 负责人: ANIRUDDHA DEB
• 金额: $ 2.17万
• 依托单位: ILLINOIS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361314
• 关键词: Biophysics; Cisplatin; Funding; Grant; Growth; Homeostasis; Image; Malignant - descriptor; Malignant neoplasm of pancreas; Metals; National Center for Research Resources; Oral; Pancreas; Pharmaceutical Preparations; Play; Principal Investigator; Research; Research Infrastructure; Resources; Role; Sampling; Source; Survival Rate; Tissue Model; Tissues; Trace Elements; United States National Institutes of Health; Zinc; base; chemotherapy; cost; malignant breast neoplasm; tumor progression; zinc-binding protein; Biophysics; Cisplatin; Funding; Grant; Growth; Homeostasis; Image; Malignant - descriptor; Malignant neoplasm of pancreas; Metals; National Center for Research Resources; Oral; Pancreas; Pharmaceutical Preparations; Play; Principal Investigator; Research; Research Infrastructure; Resources; Role; Sampling; Source; Survival Rate; Tissue Model; Tissues; Trace Elements; United States National Institutes of Health; Zinc; base; chemotherapy; cost; malignant breast neoplasm; tumor progression; zinc-binding protein

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The zinc transporter ZIP4 is over expressed in most pancreatic cancer and is a malignant factor in cancer progression. Silencing of ZIP4 is thought to inhibit pancreatic cancer growth and increases the survival rate. Recent studies indicated that zinc transport and zinc homeostasis play important roles in cancer progression, especially in pancreatic cancer and breast cancer. Recent studies have predicted that there might be correlation between metals Zn, Fe and Cu in pancreatic cancer. Based on these recent predictions about trace elements might play an important role in pancreatic cancer. We have performed XRF imaging at BioCAT beam line on pancreatic tissue models (samples were control, Cisplatin chemotherapy treated and oral Drug MI- 219 treated). We have observed an increase of the metal levels with treatment, changes in the ratio of Cu to Zn and Fe to Zn.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 锌转运蛋白Zip4在大多数胰腺癌中都过度表达，并且是癌症进展的恶性因子。 ZIP4的沉默被认为会抑制胰腺癌的生长并增加生存率。最近的研究表明，锌的运输和锌稳态在癌症进展中起着重要作用，尤其是在胰腺癌和乳腺癌中。最近的研究预测，胰腺癌中金属，Fe和Cu之间可能存在相关性。基于这些最新预测，有关痕量元素可能在胰腺癌中起重要作用。我们已经在胰腺组织模型的BioCat束系上进行了XRF成像（样品是对照，接受治疗的顺铂化学疗法和接受口服药物MI-219治疗的）。我们已经观察到金属水平随处理的增加，Cu与Zn与Fe与Zn的比率的变化。