ADIABATIC MAGNETIZATION PREPARATION PULSE FOR T2-CONTRAST AT 7 TESLA

7 特斯拉 T2 对比度的绝热磁化准备脉冲

• 批准号: 8362923
• 负责人: Priti Balchandani
• 金额: $ 1.95万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362923
• 关键词: Diagnosis; Disease; Funding; Grant; Magnetic Resonance; Magnetic Resonance Imaging; National Center for Research Resources; Physiologic pulse; Preparation; Principal Investigator; Research; Research Infrastructure; Resolution; Resources; Source; Techniques; Technology; Training; United States National Institutes of Health; Weight; cost; design; in vivo; nervous system disorder; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. High-resolution MRI at 7T has the potential to provide tremendous improvement in the diagnosis and treatment of a wide range of neurological diseases. High-resolution T2-weighted sequences are sensitive for assessing subtle structural abnormalities associated with many of these diseases [1]. Unfortunately, conventional T2-weighted sequences, such as Fast Spin Echo (FSE), utilize a train of high flip-angle Shinnar Le-Roux (SLR) [2] refocusing pulses that are very susceptible to the severe B1 inhomogeneity and SAR limitations observed at 7T. We propose an alternative adiabatic magnetization preparation (AMP) technique to obtain B1-insensitive T2-contrast at 7T. A BIR-4 pulse [3,4] with a flip angle of 0¿ with delays inserted between segments is used to introduce T2 decay. An AMP pulse was designed for use at 7T and validated with phantom and in vivo experiments.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 7T时高分辨率MRI有可能在诊断和治疗方面提供巨大改善 神经系统疾病范围。高分辨率T2加权序列对评估微妙的结构很敏感 与许多这些疾病有关的异常[1]。不幸的是，常规的T2加权序列，例如 快速自旋回声（FSE），使用一列高flip-angle shinnar le-loux（slr）[2]重新聚焦非常易感的脉冲 在7T处观察到严重的B1不均匀性和SAR限制。我们提出了替代绝热磁化 制备技术（AMP）技术以7T处获得B1不敏感的T2对比度。一个BiR-4脉冲[3,4]，额定角为0 段落之间插入的延迟用于引入T2衰减。 AMP脉冲设计用于7T并进行了验证 幻影和体内实验。