HIGH-RESOLUTION FMRI OF HIPPOCAMPAL SUBFIELD CONTRIBUTIONS TO EPISODIC MEMORY

海马亚区对情景记忆贡献的高分辨率 FMRI

• 批准号: 8362902
• 负责人: Alison R Preston
• 金额: $ 1.3万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362902
• 关键词: Address; Annual Reports; Attention; Dependence; Episodic memory; Event; Functional Imaging; Functional Magnetic Resonance Imaging; Funding; Grant; Hippocampal Formation; Hippocampus (Brain); Human; Individual; Learning; Magnetic Resonance; Medial; Memory; National Center for Research Resources; Nature; Organism; Principal Investigator; Reading; Research; Research Infrastructure; Resolution; Resources; Retrieval; Role; Source; Structure; Technology; Temporal Lobe; Testing; United States National Institutes of Health; Visit; abstracting; cost; dentate gyrus; flexibility; imaging modality; memory process; research study; theories

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Episodic memorymemory for individual eventspermits an organism to bridge the past with the present, providing information about prior events that serves to inform present decisions and action. Episodic memory critically depends on the medial temporal lobe (MTL) circuit, which is composed of multiple structures, including the hippocampal formation [dentate gyrus (DG), CA fields, and subiculum (SUB)] and the surrounding entorhinal (ERc), perirhinal (PRc), and parahippocampal (PHc) cortices. Though decades of research have aimed to characterize the role of MTL in episodic memory, fundamental questions remain regarding the functional contributions of specific MTL substructures. Recent advances in functional imaging methods have made it possible to address these questions in humans. Our research uses high-resolution fMRI to delineate the role of hippocampal subfields and MTL cortical structures in the encoding and retrieval of episodic memories. The experiments test anatomically-informed theory-driven hypotheses regarding the nature of episodic memory and its dependence on MTL function. The research further examines optimal learning parameters to promote the flexible, generative use of episodic memory, and the potential impact of motivational salience and attention on episodic memory processing and MTL function. To read about other projects ongoing at the Lucas Center, please visit http://rsl.stanford.edu/ (Lucas Annual Report and ISMRM 2011 Abstracts)

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 单个事件的情节记忆记忆允许有机体与现在桥接过去，提供 有关旨在告知当前决策和行动的先前事件的信息。情节记忆严重取决于 内侧颞叶（MTL）电路，该电路由多个结构组成，包括海马形成 [齿状回（DG），CA田和下丘（sub）]和周围的内嗅（ERC），Perirhinal（PRC）和 Parahampocampal（PHC）皮质。尽管数十年的研究旨在表征MTL在情节中的作用 记忆，关于特定MTL子结构的功能贡献仍然存在的基本问题。最近的 功能成像方法的进步使得在人类中解决这些问题成为可能。我们的研究使用 高分辨率fMRI描述了海马子场和MTL皮质结构在编码和检索中的作用 情节记忆。该实验检验了关于理论驱动的解剖学驱动的假设 情节记忆及其对MTL功能的依赖。该研究进一步研究了最佳学习参数 促进情节记忆的灵活，生成的使用，以及动机显着性和关注的潜在影响 在情节内存处理和MTL功能上。 要了解卢卡斯中心正在进行的其他项目，请访问http://rsl.stanford.edu/（卢卡斯年度报告和 ISMRM 2011摘要）