Oscillatory mechanisms of context dependent cognitive maps in human memory

人类记忆中情境相关认知图的振荡机制

基本信息

批准号：
10317842
负责人：
Alison R Preston
金额：
$ 23.78万
依托单位：
UNIVERSITY OF TEXAS AT AUSTIN
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-02 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10317842
关键词：
Address Area Behavior Behavioral Brain Brain imaging Clinical Code Cognitive Complex Coupled Coupling Decision Making Destinations Detection Disease Electroencephalography Electrophysiology (science)Epilepsy Feedback Foundations Frequencies Functional Magnetic Resonance Imaging Hippocampus (Brain)Human Impairment Influentials Knowledge Learning Learning Disorders Lesion Light Location Maps Measures Medial Mediating Memory Memory Disorders Mental disorders Methods Monitor Patients Phase Play Population Prefrontal Cortex Process Proxy Publishing Retrieval Rewards Rodent Role Sampling Scheme Schizophrenia Seizures Services Signal Transduction Therapeutic Work autism spectrum disorder base comparative experimental study flexibility insight memory encoding memory retrieval nervous system disorder novel relating to nervous system response temporal measurement theories tool translational approach virtual virtual environment way finding

项目摘要

Project Summary/Abstract How does memory guide our choices in particular locations and contexts? How does our brain accomplish this? Memory, navigation, and context dependent decision-making are essential for adaptive human behavior and are impaired in several neurological and psychiatric disorders. This proposal aims to identify the basic mechanisms mediating context dependent memory representations in the human brain towards advancing refined therapeutic tools for memory enhancement in clinical populations. More specifically, this proposal will investigate the neural basis of context dependent memory encoding and retrieval, behavior that enables us to flexibly act in the world according to particular situations. Influential human brain imaging and lesion studies have identified that the hippocampus (HPC) and the medial prefrontal cortex (mPFC), along with their interactions, are where memory and navigational computations take place. However, these studies have poor temporal resolution and do not directly measure electrical activity. Thus, we don't understand how context dependent memories are formed and retrieved in humans. The proposed experiments will utilize direct human brain recordings from HPC and mPFC in epilepsy patients undergoing invasive seizure monitoring to yield new insight into the electrophysiological basis of human memory. Patients perform a context dependent learning and memory task in which objects are associated with different rewards depending on context. The task is embedded in a virtual environment, enabling comparisons of neural signatures of both spatial navigation and associative memory. We hypothesize that synchronous, “phase coded” oscillatory activity within and between the HPC and mPFC supports context dependent memory. Aiming to identify the unique and overlapping electrophysiological mechanisms mediating context dependent representations, this proposal is likely to transform our understanding of how the human brain coordinates its activity in the service of adaptive human behavior. This work will also shed new light on how the human brain utilizes complex, context dependent associations to provide insight into putative mechanisms mediating impairments in several clinical populations.

项目摘要/摘要内存如何指导我们的选择在特定位置和环境中？这个记忆，导航和上下文依赖的决策对于自适应并在严重的神经和精神病中受到损害。介导上下文垂直记忆的机制在人脑中的内存代表朝着前进更具体地说，该提案意志将会在临床普及中提高精致的治疗工具。研究上下文依赖记忆编码和检索的神经基础，使我们能够根据特定形式的人类脑成像和病变研究的灵活性已经确定海马（HPC）和内侧前额叶皮层（MPFC）相互作用是内存和导航计算计算。时间分辨率，不直接测量电活动。依赖的记忆是在人类中形成的。 HPC和MPFC的脑记录癫痫患者侵入性监测以产生新的深入了解人类记忆的电物质基础。与对象相关的内存任务，具体取决于上下文嵌入在虚拟环境中，可以比较空间导航和联想记忆。 HPC和MPFC指示上下文依赖性内存。电生理学机制介导依赖上下文的代表，此建议可能会改变我们对人脑的理解可以协调其在适应性人类的服务中的活动行为。提供洞察力的私密机制的关联，介导了几个临床人群中的损伤。