SIMULATION OF CORONARY ARTERY BYPASS GRAFT AND SURGICAL VENTRICULAR RESTORATION

冠状动脉搭桥术和心室修复手术的模拟

• 批准号: 8362806
• 负责人: Andrew D. McCulloch
• 金额: $ 2万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362806
• 关键词: Anatomy; Biomedical Computing; Blood flow; Cardiac; Cardiovascular Diseases; Computer software; Coronary Artery Bypass; Coronary artery; Funding; Grant; Heart failure; Magnetic Resonance Imaging; Myocardial Ischemia; National Center for Research Resources; Operative Surgical Procedures; Patients; Physics; Postoperative Period; Principal Investigator; Public Domains; Research; Research Infrastructure; Research Personnel; Resources; Simulate; Software Tools; Source; Surgeon; United States National Institutes of Health; Ventricular; base; cost; restoration; simulation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The overall objective of this project is to develop and deploy a public-domain software tool that will enable cardiac surgeons and cardiovascular disease researchers to simulate the effects of coronary artery bypass graft (CABG) and surgical ventricular restoration (SVR) on patients with ischemic heart failure. The aims are to: 1. Obtain pre- and post-operative CT and MRI exams on STICH patients (n = 10) in order to quantify their LV wall geometry and regional function and coronary artery anatomy and blood flow. 2. Develop physics-based simulations of CABG and SVR using only public-domain software. Hypothesis: There is a benefit of SVR + CABG over CABG alone in the treatment of patients with ischemic heart failure.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 该项目的总体目的是开发和部署公共域 软件工具将使心脏外科医生和心血管疾病研究人员能够 模拟冠状动脉搭桥移植物（CABG）和手术心室的影响 对缺血性心力衰竭患者的恢复（SVR）。目的是： 1。在Stich患者（n = 10）上获得术前和后CT和MRI检查 量化其LV壁几何形状和区域功能以及冠状动脉解剖学以及 血流（量。 2。仅使用公共域软件开发基于物理的CABG和SVR模拟。 假设：仅在患者治疗中，SVR + CABG比CABG有一个好处 缺血性心力衰竭。