NEUROCHEMICAL CORRELATES OF PATHOLOGY IN SPINOCEREBELLAR ATAXIAS

脊髓小脑共济失调病理学的神经化学相关性

• 批准号: 8362815
• 负责人: Gulin Oz
• 金额: $ 2.27万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362815
• 关键词: Ataxia; Brain; Collaborations; Funding; Goals; Grant; Histology; Magnetic Resonance Imaging; Medicine; Modeling; Mus; Mutation; NMR Spectroscopy; National Center for Research Resources; Nerve Degeneration; Pathology; Principal Investigator; Research; Research Infrastructure; Resources; Source; Spinocerebellar Ataxias; United States National Institutes of Health; college; cost; neurochemistry

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Neurochemical Correlates of Pathology in Spinocerebellar Ataxias (in collaboration with Dr.s Harry Orr and Brent Clark, Lab Medicine and Pathology and Huda Y. Zoghbi, Baylor College of Medicine, supported by R21 NS060253 and Bob Allison Ataxia Research Center, PI Oz): In this project our goal is to validate the MRS markers of neurodegeneration by comparison to histology findings in the same brains. For this purpose we utilize multiple mouse lines that carry the SCA1 mutation, including a treatment model, in order to determine if high field MRS is sensitive to early, pre-symptomatic neurochemical alterations, as well as to the reversal of such changes with treatment.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 脊椎小脑共济失调中病理学的神经化学相关性（与Harry Orr博士和Brent Clark博士合作，实验室医学和病理学以及Baylor医学学院的Huda Y. Zoghbi，由R21 NS060253和Bob Allison Ataxia Researtial Center在Project中，由R21 NS060253和PIDIDANIDED SARGIDATIDS CRAMITIAD SARGIDATIDS CARGIDATIDIAD SARGIDATIDIDS CRANDIDARIDED SARGIASS ISS验证为MR Skinistiad同一大脑中的发现。 为此，我们利用了携带SCA1突变（包括治疗模型的）的多种小鼠系，以确定高场MRS是否对早期的，症状前神经化学改变以及治疗中这种变化的反转。