NONINVASIVE QUANTITATION OF BIOCHEM CHANGESPARKINSONS

帕金森病生物化学变化的无创定量

• 批准号: 8362816
• 负责人: Gulin Oz
• 金额: $ 2.27万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362816
• 关键词: Affect; Biochemical; Biological Markers; Brain region; Collaborations; Data; Disease; Foundations; Funding; Goals; Grant; Human; Iron; Magnetic Resonance Imaging; Measures; Methods; NMR Spectroscopy; National Center for Research Resources; Neurology; Parkinson Disease; Patients; Principal Investigator; Research; Research Infrastructure; Resources; Source; Spectrum Analysis; Structure; Substantia nigra structure; United States National Institutes of Health; cost; improved; neurochemistry; trend

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Noninvasive Quantitation of Biochemical Changes in the Human Substantia Nigra in Parkinson's Disease (in collaboration with Dr. Paul Tuite, Neurology, supported by Dana Foundation): The goal in this project is to measure neurochemical alterations by high field MRS in the substantia nigra of patients with Parkinson's disease. Substantia nigra is the brain region primarily affected by Parkinson's disease and neurochemical alterations detected by MRS in this region may be utilized as biomarkers as well as improve our understanding of disease mechanisms. However, MRS of substantia nigra is very challenging due to the small size and iron content of the structure. Our preliminary data at a 4 Tesla scanner has demonstrated the feasibility of quantifying 10 neurochemicals in patients and controls and trends for some neurochemicals to change in patients. Our goal in this project was to move the spectroscopy methods to our 7 Tesla scanner in order to improve sensitivity and to be able to localize better in the substantia nigra.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 帕金森氏病中人类本质的生物化学变化的无创定量（与Dana Foundation的Paul Tuite博士合作）：该项目的目的是衡量帕金森病患者的基因氏病的高领域MRS的神经化学改变。 黑质尼格拉是主要受帕金森氏病影响的大脑区域，该地区MRS检测到的神经化学改变可能被用作生物标志物，并提高了我们对疾病机制的理解。但是，由于结构的尺寸和铁含量较小，因此黑质的MRS非常具有挑战性。我们在4特斯拉扫描仪上的初步数据证明了一些神经化学物质在患者中量化10个神经化学物质的可行性，以使某些神经化学物质改变患者的变化。 我们在该项目中的目标是将光谱法移至我们的7种特斯拉扫描仪，以提高灵敏度并能够在底底尼格拉（Baseia Nigra）中更好地本地化。