RAT MODEL OF ACUTE MYOCARDIAL INJURY WITH ISOPROTERENOL

异丙肾上腺素大鼠急性心肌损伤模型

• 批准号: 8363220
• 负责人: BRAIN BERRIDGE
• 金额: $ 1.84万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363220
• 关键词: Acute; Address; Affect; Animals; Area; Cardiac; Cardiac Output; Cardiac Volume; Data; EFRAC; Funding; Goals; Grant; Histologic; Histology; Injury; Isoproterenol; Left; Location; Microscopy; Modeling; Myocardial; National Center for Research Resources; Nature; Online Systems; Principal Investigator; Rattus; Reporting; Research; Research Design; Research Infrastructure; Resolution; Resources; Source; Stroke Volume; Subcutaneous Injections; System; Testing; Thick; United States National Institutes of Health; cost; in vivo

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This project was reactivated: Goals 1. Assess the impact of isopeterinol injury on cardiac function using micro-CT: 2. Assess the nature and distribution of injury using MR histology Study Design Animals: 12 Fisher 344 femal (140-160 gm) : 6 control; 6 treated Test article: Isopeterenol @ 32 mg/kg subcutaneous injection CT: Quantitative endpoints - total cardiac volume; left, right, and septal wall thickness; EDV, ESV, ejection fraction, stroke volume, cardiac output, fractional shortening MR microscopy: Volume and location of affected areas @ histologic resolution (MR < 30 microns) Final Report: A final report will be composed addressing the questions articulated in the goals. All data will be made available to GSK via the web-based delivery system from the Center for In Vivo Microscopy.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 该项目已重新激活： 目标 1。使用MICRO-CT评估异磷醇损伤对心脏功能的影响： 2。使用MR组织学评估损伤的性质和分布 研究设计 动物：12 Fisher 344 Femal（140-160 gm）：6对照； 6治疗 测试文章：Isopeterenol @ 32 mg/kg皮下注射 CT：定量终点 - 总心脏量；左，右，隔膜厚度； EDV，ESV，射血分数，中风量，心输出量，分数缩短 MR显微镜： @组织学分辨率的受影响区域的体积和位置（MR <30微米） 最终报告：最终报告将撰写，以解决目标中阐明的问题。所有数据将通过基于Web的交付系统从体内显微镜中心提供给GSK。