MEDICAL STRUCTURAL GENOMICS OF PATHOGENIC PROTOZOA

致病原虫的医学结构基因组学

• 批准号: 8362415
• 负责人: ETHAN A MERRITT
• 金额: $ 0.06万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至 2012-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362415
• 关键词: African Trypanosomiasis; Biochemical; Chemical Models; Collaborations; Complex; Crystallography; Development; Disease; Drug Design; Funding; Grant; Infection; Ligands; Malaria; Medical; National Center for Research Resources; Output; Pharmaceutical Preparations; Principal Investigator; Proteins; Protozoa; Radiation; Research; Research Infrastructure; Resources; Scourge; Screening procedure; Source; Structure; United States National Institutes of Health; Universities; Washington; World Health; base; beamline; cost; drug candidate; pathogen; structural biology; structural genomics

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This proposal constitutes the crystallographic component of a collaboration among several research groups at the University of Washington (PIs Ethan Merritt, Dustin Maly, Fred Buckner, Wesley van Voorhis, Erkang Fan, Christophe Verlinde, Wim Hol). Access to SSRL beamlines will allow us to determine crystal structures of key proteins and protein:ligand complexes from a set of important eukaryotic pathogens. The previous 4 years of study has laid the groundwork for subsequent biochemical studies and structure-based drug design targeting the corresponding diseases. These include major world scourges (malaria, sleeping sickness, Chagas? disease) and other infections with a disproportionate impact on Third World health. Crystallography will be combined with the output of chemical modeling and biochemical screening to conduct ligand discovery, to identify potential drug leads, and to provide SAR for the development of candidate drugs.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 该建议构成了华盛顿大学几个研究小组合作的晶体学组成部分（Pis Ethan Merritt，Dustin Maly，Fred Buckner，Wesley van Voorhis，Erkang Fan，Christophe Verlinde，Wim Hol）。进入SSRL束线将使我们能够确定关键蛋白质和蛋白质的晶体结构：一组重要的真核病原体的配体配合物。前4年的研究为随后的生化研究和针对相应疾病的基于结构的药物设计奠定了基础。其中包括主要的世界祸害（疟疾，睡眠疾病，chagas？疾病）和其他对第三世界健康影响不成比例的感染。晶体学将与化学建模和生化筛选的输出结合使用，以进行配体发现，以识别潜在的药物铅并为候选药物的开发提供SAR。