FOR THE STUDY OF FAT REDISTRIBUTION AND METABOLIC CHANGE IN HIV INFECTION

用于研究 HIV 感染中的脂肪重新分布和代谢变化

• 批准号: 8361469
• 负责人: Carl Grunfeld
• 金额: $ 1.47万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361469
• 关键词: Adult; Disease; Elderly; Fatty acid glycerol esters; Funding; Grant; HIV; HIV Infections; Magnetic Resonance Imaging; Mass Spectrum Analysis; Metabolic; Methods; Muscle; National Center for Research Resources; Principal Investigator; Research; Research Infrastructure; Resources; Skeletal Muscle; Source; United States National Institutes of Health; Woman; age related; aged; antiretroviral therapy; biomedical resource; cost; men; muscle form

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Background. Skeletal muscle (SM) mass decreases with advanced age and with disease in HIV infection. It is unknown whether age-related muscle loss is accelerated in the current era of antiretroviral therapy, and which factors might contribute to muscle loss among HIV-infected adults. We hypothesized that muscle mass would be lower and decline faster in HIV-infected adults than in similar-aged controls. Methods. Whole-body 1H-magnetic resonance imaging (MRI) was used to quantify regional and total SM in 399 HIV-infected and 204 Control men and women at baseline and 5 years later. Multivariable regression identified associated factors.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 背景。 骨骼肌（SM）质量随着年龄的增长和艾滋病毒感染而降低。 在当前的抗逆转录病毒疗法时代，与年龄相关的肌肉损失是否加速是尚不清楚的，哪些因素可能导致HIV感染的成年人的肌肉损失。我们假设在感染HIV的成年人中，肌肉质量将比相似的对照组低，并且下降的速度要快。方法。全身1H-磁共振成像（MRI）用于量化399例HIV感染的区域和总SM，在基线和5年后的204名对照男女中进行对照。多变量回归确定了相关因素。