CRYSTAL STRUCTURES OF RIBOSOME COMPLEXES

核糖体复合物的晶体结构

• 批准号: 8362118
• 负责人: HARRY F NOLLER
• 金额: $ 4.88万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至 2012-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362118
• 关键词: Complex; Funding; Goals; Grant; Ligands; Messenger RNA; National Center for Research Resources; Principal Investigator; Radiation; Research; Research Infrastructure; Resolution; Resources; Ribosomes; Source; Structure; Transfer RNA; Translations; United States National Institutes of Health; cost; movie; structural biology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The focus of our structural studies on the 70S ribosome is to obtain high resolution structures of different functional complexes corresponding to different states of the ribosome during translation. Ribosome complexes containing various combinations of mRNA, tRNAs, translational factors and other ligands are being constructed and crystallized for structural analysis. Our ultimate goal is to assemble the resulting structures into a high-resolution 'movie' that will provide a description of translation as it occurs on the ribosome.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 我们在70S核糖体上的结构研究的重点是获得与翻译过程中与核糖体不同状态相对应的不同功能复合物的高分辨率结构。核糖体复合物包含mRNA，TRNA，翻译因子和其他配体的各种组合，正在构建并结晶以进行结构分析。我们的最终目标是将所得的结构组装成高分辨率的“电影”，该结构将提供核糖体上发生的翻译的描述。