CRYSTAL STRUCTURES OF RIBOSOME COMPLEXES

核糖体复合物的晶体结构

• 批准号: 7954338
• 负责人: HARRY F NOLLER
• 金额: $ 1.14万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7954338
• 关键词: Complex; Computer Retrieval of Information on Scientific Projects Database; Funding; Goals; Grant; Institution; Ligands; Messenger RNA; Research; Research Personnel; Resolution; Resources; Ribosomes; Source; Structure; Translations; United States National Institutes of Health; movie; structural biology; synchrotron radiation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The focus of our structural studies on the 70S ribosome is to obtain high resolution structures of different functional complexes corresponding to different states of the ribosome during translation. Ribosome complexes containing various combinations of mRNA, tRNAs, translational factors and other ligands are being constructed and crystallized for structural analysis. Our ultimate goal is to assemble the resulting structures into a high-resolution 'movie' that will provide a description of translation as it occurs on the ribosome.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 我们在70S核糖体上的结构研究的重点是获得与翻译过程中与核糖体不同状态相对应的不同功能复合物的高分辨率结构。核糖体复合物包含mRNA，TRNA，翻译因子和其他配体的各种组合，正在构建并结晶以进行结构分析。我们的最终目标是将所得的结构组装成高分辨率的“电影”，该结构将提供核糖体上发生的翻译的描述。