STRUCTURE-BASED DEVELOPMENT OF INHIBITORS OF VIRAL ENZYMES

基于结构的病毒酶抑制剂的开发

• 批准号: 8362088
• 负责人: Katherine S Bateman
• 金额: $ 0.03万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至 2012-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362088
• 关键词: Animals; Antiviral Agents; Binding; Chymase; DNA-Directed RNA Polymerase; Development; Enzymes; Evolution; Funding; Grant; Human; National Center for Research Resources; Pharmaceutical Preparations; Principal Investigator; RNA Viruses; Radiation; Research; Research Infrastructure; Resources; Source; Structure; United States National Institutes of Health; Viral; Virus Inhibitors; Work; base; cost; design; inhibitor/antagonist; pathogen; structural biology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Many important pathogens of humans and animals belong to the positive-sense, single-stranded RNA viruses. Enzymes such as RNA polymerase and the chymotrypsin-like proteases are absolutely required for viral replication. Therefore, these enzymes and their precursors are ideal targets for the design of antiviral drugs. We and others have determined crystal structures of a number of viral enzymes from this group, including some with bound inhibitors. This work is valuable for the understanding of viral evolution, enzymatic mechanisms and the development of anti viral drugs. We are pursuing a project to develop different and more effective inhibitors of several viral enzymes.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 人类和动物的许多重要病原体属于阳性，单链的RNA病毒。病毒复制绝对需要酶，例如RNA聚合酶和胰凝乳蛋白酶样蛋白酶。因此，这些酶及其前体是设计抗病毒药物的理想靶标。我们和其他人确定了该组的许多病毒酶的晶体结构，包括一些具有结合抑制剂的晶体结构。这项工作对于理解病毒进化，酶促机制和抗病毒药物的发展很有价值。我们正在追求一个项目，以开发几种病毒酶的不同，更有效的抑制剂。