INDOCYANINE GREEN PHOTODYNAMIC THERAPY FOR VASCULAR LESIONS

吲哚菁绿光动力疗法治疗血管病变

• 批准号: 8362680
• 负责人: BERNARD CHOI
• 金额: $ 0.31万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362680
• 关键词: Animal Model; Biotechnology; Blood Circulation; Blood Vessels; Diffuse; Funding; Grant; Indocyanine Green; Lasers; Lesion; Mus; National Center for Research Resources; Photochemotherapy; Physiologic pulse; Principal Investigator; Research; Research Infrastructure; Resources; Side; Simulate; Skin; Source; Spottings; United States National Institutes of Health; alexandrite; cost; interest; irradiation; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Our experiments aim to evaluate the effect of ICG-PDT on mouse window chamber vasculature (an animal model which simulates PWS vasculature). Specifically, we are interested in determining the level of vascular shutdown achieved with ICG-PDT. Mice will receive ICG followed by laser irradiation. ICG will be injected retroorbitally allowing the ICG to diffuse into the bloodstream. Following a 1-minute delay, the epidermal side of the skin-fold will be irradiated with a GentleLASE 755 nm alexandrite laser; pulse duration and spot size will be 3 ms and 10 mm respectively. Mice will then be exposed to radiant exposures of 30, 40 or 50 J/cm2.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 我们的实验旨在评估ICG-PDT对小鼠窗户室脉管系统的影响（模拟PWS脉管系统的动物模型）。 具体而言，我们有兴趣确定ICG-PDT达到的血管关闭水平。 小鼠将接收ICG，然后接受激光照射。 ICG将被注入倒弹性，使ICG扩散到血液中。 延迟1分钟后，刺激755 nm Alexandrite激光器将辐射皮肤的表皮侧；脉冲持续时间和斑点大小分别为3 ms和10 mm。 然后，小鼠将暴露于30、40或50 J/cm2的辐射暴露。