METAL NANOPARTICLES AS IMAGING, TARGETING, & THERAPEUTIC AGENTS FOR CANCER

金属纳米颗粒作为成像、靶向、

• 批准号: 8362641
• 负责人: ANTHONY J DURKIN
• 金额: $ 1.71万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362641
• 关键词: Affinity; Antineoplastic Agents; Biotechnology; Funding; Grant; Image; Imaging Device; Kinetics; Lasers; Ligands; Malignant Neoplasms; Mediating; Metals; Molecular; Monitor; Mus; National Center for Research Resources; Principal Investigator; Property; Research; Research Infrastructure; Resources; Shapes; Simulate; Source; System; Techniques; Therapeutic Agents; Tissues; United States National Institutes of Health; cancer imaging; cancer therapy; cost; in vivo; interest; nanoparticle; novel; tumor; tumor xenograft

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Metal nanoparticles (NP) have gained interest as a novel platform for integrated cancer imaging and therapy due to their highly desirable spectral and molecular properties. While the targeting of macromolecular anti-cancer drugs has been studied in great detail, there is currently little known about the dynamics of metal nanoparticle targeting primarily due to the lack of techniques to monitor them in vivo. The proposed project will develop Modulated Imaging (MI) as a three dimensional quantitative imaging tool to monitor NP's in bulk tissue (Aim 1). We will validate this system in tissue simulating phantoms and in murine tumor xenografts in vivo. This system will be used to study the kinetics of NP tumor targeting (Aim 2). In particular, we will study the effect of nanoparticle size, shape, and targeting strategy (i.e. passive vs. ligand-mediated) on the accumulation rate and affinity in murine tumors.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 金属纳米颗粒（NP）由于其高度理想的光谱和分子特性而引起了综合癌症成像和治疗的新平台的兴趣。虽然对大分子抗癌药物的靶向进行了详细的研究，但目前对金属纳米颗粒的动力学目前鲜为人知，主要是由于缺乏在体内监测它们的技术。拟议的项目将开发调制成像（MI）作为三维定量成像工具，以监测散装组织中的NP（AIM 1）。我们将在模拟幻象和体内模拟鼠类肿瘤异种移植物中验证该系统。该系统将用于研究NP肿瘤靶向的动力学（AIM 2）。特别是，我们将研究纳米颗粒大小，形状和靶向策略（即被动与配体介导的）对鼠肿瘤的累积率和亲和力的影响。