ASSOCIATION OF REGIONS WITH HYPERTENSION IN NIGERIAN FAMILIES

尼日利亚家庭高血压地区协会

• 批准号: 7956498
• 负责人: XIAOFENG ZHU
• 金额: $ 0.48万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7956498
• 关键词: African; Blood Pressure; Chromosomes, Human, Pair 6; Chromosomes, Human, Pair 7; Computer Retrieval of Information on Scientific Projects Database; Data; Environmental Exposure; Family; Frequencies; Funding; Genes; Genotype; Grant; Haplotypes; Heritability; Human Genetics; Hypertension; Individual; Institution; PARK2 gene; Population; Predisposition; Research; Research Personnel; Resources; Risk; Source; Staging; United States National Institutes of Health; base; cardiovascular risk factor; genetic analysis; genome-wide linkage; trait

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hypertension shares a level of heritability similar to many other traits related to cardiovascular risk; however, specific susceptibility loci have been difficult to localize. We conducted a multi-stage study of blood pressure as a continuous trait in a low-risk West African population where it was anticipated that environmental exposures would be reduced in complexity and intensity. In our earlier genome-wide linkage study for blood pressure in this population strong linkage evidence was noted on chromosomes 6 and 7. We subsequently genotyped a total of 3431 tag SNPs in three regions (viz, 152.68  165.99 Mb on chromosome 6, 0.29  20.67 Mb and 104.09  123.06 Mb on chromosome 7) in 713 individuals from 199 families. We conducted family-based association analysis using individual SNPs and associated haplotypes. After correction for multiple comparisons, six intronic SNPs and one intergenic SNP achieved nominal statistical significance (p < 0.05) for association with blood pressure. The associated intronic SNPs include two in the PARK2 gene on chromosome 6; two in the KCND2, and one each in the C7orf58 and HDAC9 genes on chromosome 7. The intergenic SNP is located between the RPA3 and GLCCI1 genes on chromosome 7. The haplotypes on which these SNPs resided were more strongly associated with blood pressure than their respective single SNPs. The frequency of the "at risk" haplotypes ranged from 14% to 48%. These data provide preliminary evidence that regions on chromosomes 6 and 7 may influence susceptibility to elevations in blood pressure.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 高血压与许多其他与心血管风险相关的特征具有相似的遗传性水平。然而，特定的易感位点很难定位。 我们对血压作为低风险西非人群的连续特征进行了多阶段研究，预计环境暴露的复杂性和强度将会降低。在我们早期针对该人群血压的全基因组连锁研究中，在 6 号和 7 号染色体上注意到了强有力的连锁证据。随后，我们对三个区域中总共 3431 个标签 SNP 进行了基因分型（即 6 号染色体上的 152.68 165.99 Mb，0.29来自 713 个个体的 7 号染色体上有 20.67 Mb 和 104.09 123.06 Mb 199个家庭。我们使用个体 SNP 和相关单倍型进行了基于家族的关联分析。经过多重比较校正后，6 个内含子 SNP 和 1 个基因间 SNP 与血压的相关性达到名义统计学显着性 (p < 0.05)。相关的内含子 SNP 包括 6 号染色体 PARK2 基因中的两个； KCND2 中有两个，7 号染色体上的 C7orf58 和 HDAC9 基因各有一个。基因间 SNP 位于 7 号染色体上的 RPA3 和 GLCCI1 基因之间。这些 SNP 所在的单倍型与血压的相关性比它们各自的单倍型更强。单个 SNP。 “有风险”单倍型的频率范围为 14% 至 48%。这些数据提供了初步证据，表明 6 号和 7 号染色体上的区域可能影响血压升高的易感性。