COMPARISON OF A UNIFIED APPROACH AND THE TDT IN THE FRAMINGHAM HEART STUDY

Framingham 心脏研究中统一方法与 TDT 的比较

• 批准号: 7956501
• 负责人: XIAOFENG ZHU
• 金额: $ 0.48万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7956501
• 关键词: Blood Pressure; Computer Retrieval of Information on Scientific Projects Database; Data; Diastolic blood pressure; Family; Framingham Heart Study; Funding; Grant; Heart; Human Genetics; Hypertension; Institution; Population; Principal Component Analysis; Research; Research Personnel; Resources; Sampling; Source; Stratification; Testing; United States National Institutes of Health; base; genetic analysis; systolic hypertension; trait; transmission process

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Population stratification is one of the major causes of spurious associations in association studies. A unified association approach (FamCC) based on principal component analysis can overcome the effect of population stratification, as well as make use of both family and unrelated samples combined to increase power. In this study, we compared FamCC and the transmission disequilibrium test (TDT) using data on hypertension, systolic blood pressure (SBP) and diastolic blood pressure (DBP) in the Framingham heart study. Our study indicated FamCC has reasonable type I error for both unrelated samples and family samples for all three traits. For the binary trait hypertension, we found results from FamCC were inconsistent with those from the TDT. We discuss the reasons for this inconsistency. After correcting for multiple tests, we did not detect any significant SNPs by either FamCC or the TDT. The results from FamCC and the TDT were most consistent for the quantitative trait DBP and least consistent for the binary trait hypertension.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 人群分层是关联研究中虚假关联的主要原因之一。基于主成分分析的统一关联方法（FamCC）可以克服群体分层的影响，并利用家庭和无关样本组合来增加功效。在本研究中，我们使用 Framingham 心脏研究中的高血压、收缩压 (SBP) 和舒张压 (DBP) 数据比较了 FamCC 和传递不平衡检验 (TDT)。我们的研究表明，对于所有三个性状，FamCC 对于不相关样本和家庭样本都具有合理的 I 类错误。对于二元性状高血压，我们发现 FamCC 的结果与 TDT 的结果不一致。我们讨论这种不一致的原因。校正多项测试后，我们没有通过 FamCC 或 TDT 检测到任何显着的 SNP。 FamCC 和 TDT 的结果对于 DBP 数量性状最为一致，而对于二元性状高血压则最不一致。