ADMIXTURE MAPPING OF QUANTITATIVE TRAIT LOCI FOR BMI IN AFRICAN-AMERICANS

非裔美国人 BMI 数量性状位点的混合图谱

• 批准号: 8171727
• 负责人: XIAOFENG ZHU
• 金额: $ 0.99万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171727
• 关键词: 15q26; 3q29; Admixture; African; African American; Age; American; Blood Pressure; Body mass index; Chromosomes; Computer Retrieval of Information on Scientific Projects Database; Disease; European; Family; Funding; Genes; Genome; Genotype; Grant; Heart Diseases; Hypertension; Individual; Institution; Location; Maps; Microsatellite Repeats; Nigeria; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Participant; Population; Public Health; Quantitative Trait Loci; Regression Analysis; Research; Research Personnel; Resources; Risk Factors; Source; United States National Institutes of Health; base; programs; response; sex; trait

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Obesity is a heritable trait and a major risk factor for highly prevalent common diseases such as hypertension, cardiac diseases and type 2 diabetes. Obesity is a major public health concern worldwide. Previously we showed that BMI was positively correlated with African ancestry among the African American (AA) participants in the NHLBI's Family Blood Pressure Program (FBPP). Using Individual Ancestry (IA) estimates at 284 marker locations across the genome, we now present a Quantitative Admixture Mapping (QAM) analysis of body mass index (BMI) in the same population. We used a set of unrelated individuals from Nigeria to represent the African ancestral population and the European Americans in the FBPP as the European ancestral population. The analysis was based on a common set of 284 microsatellite markers genotyped in all three groups. We considered the quantitative trait, BMI, as the response variable in a regression analysis, with the marker location specific excess of European ancestry as the explanatory variable. After suitably adjusting for different covariates such as sex, age and study center, we found strong evidence for a positive association with European ancestry at chromosome locations 3q29 and 5q14 and a negative association on chromosome 15q26. These results suggest that these regions may harbor genes influencing BMI in the AA population.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 肥胖是一种遗传特征，也是高血压、心脏病和2型糖尿病等高发常见病的主要危险因素。肥胖是全世界主要的公共卫生问题。之前我们发现，在 NHLBI 家庭血压计划 (FBPP) 的非裔美国人 (AA) 参与者中，BMI 与非洲血统呈正相关。 利用个体祖先 (IA) 对基因组中 284 个标记位置的估计，我们现在对同一人群中的体重指数 (BMI) 进行定量混合作图 (QAM) 分析。我们使用一组来自尼日利亚的无关个体来代表非洲祖先群体，并使用 FBPP 中的欧洲裔美国人作为欧洲祖先群体。该分析基于对所有三组进行基因分型的一组通用的 284 个微卫星标记。我们将数量性状 BMI 作为回归分析中的响应变量，以标记位置特定的欧洲血统过剩作为解释变量。在对性别、年龄和研究中心等不同协变量进行适当调整后，我们发现强有力的证据表明，染色体位置 3q29 和 5q14 与欧洲血统呈正相关，而染色体 15q26 则呈负相关。这些结果表明这些区域可能含有影响 AA 人群体重指数的基因。