NMDA RECEPTOR FUNCTION IN THE RAT KIDNEY

大鼠肾脏中的 NMDA 受体功能

• 批准号: 8360648
• 负责人: Karen A Munger
• 金额: $ 0.25万
• 依托单位: UNIVERSITY OF SOUTH DAKOTA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8360648
• 关键词: Animals; Basic Science; Biomedical Research; Brain; Calcium Channel; Eating; Funding; Grant; Growth; Immunohistochemistry; Ischemia; Kidney; Laboratories; Learning; N-Methyl-D-Aspartate Receptors; N-Methylaspartate; National Center for Research Resources; Operative Surgical Procedures; Physiology; Principal Investigator; Quantitative Microscopy; Rattus; Renal function; Research; Research Infrastructure; Resources; Role; Sioux Falls; Source; South Dakota; Stroke; Students; Techniques; United States National Institutes of Health; cost; gel electrophoresis; hemodynamics; interest

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Basic science research opportunities in renal physiology are available in a USD-affiliated laboratory located in Sioux Falls. Dr. Munger is interested in the role of the NMDA calcium channel in normal kidney function. NMDA has been described in the brain and is involved in plasticity and learning. NMDA is also responsible for damage sustained after ischemia ("stroke"). Dr. Munger has recently discovered the NMDA receptor in the rat kidney and is investigating the role of NMDA in normal/pathophysiological renal function in rats. The renal NMDA receptor is regulated by food intake and is involved in normal hemodynamics and growth in the kidney. Various analytical and surgical techniques are used in the laboratory including whole kidney clearances techniques, small animal surgery, gel electrophoresis, immunohistochemistry, microscopy, and quantitative analysis. Many student projects are available.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 肾脏生理学的基础科学研究机会可在位于苏福尔斯的USD附属实验室中获得。 Munger博士对NMDA钙通道在正常肾脏功能中的作用感兴趣。 NMDA已在大脑中描述，并参与了可塑性和学习。 NMDA还负责缺血后遭受的损害（“中风”）。 Munger博士最近在大鼠肾脏中发现了NMDA受体，并正在研究NMDA在大鼠正常/病理生理肾功能中的作用。 肾脏NMDA受体受食物摄入调节，并参与肾脏的正常血液动力学和生长。 实验室中使用了各种分析和手术技术，包括全肾通关技术，小动物手术，凝胶电泳，免疫组织化学，显微镜和定量分析。 有许多学生项目可用。