MOLECULAR AND GENETIC ADAPTATIONS ASSOCIATED WITH COMPULSIVE COCAINE INTAKE

与强迫性可卡因摄入相关的分子和遗传适应

• 批准号: 8357952
• 负责人: Wei-Dong Yao
• 金额: $ 1.38万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357952
• 关键词: Brain Diseases; Cocaine; Cocaine Abuse; Cocaine Dependence; Funding; Gene Expression; Goals; Grant; Intake; Mediating; Medical; Modeling; Molecular; Molecular Genetics; National Center for Research Resources; Neurobiology; New England; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Rewards; Self Administration; Source; United States National Institutes of Health; addiction; base; cocaine exposure; cost; effective therapy; neurochemistry; nonhuman primate; reward circuitry; socioeconomics; theories

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Cocaine abuse and addiction continues to be a major problem worldwide with grave medical and socioeconomic consequences, and few effective therapies exist to treat this brain disorder. A prevailing theory in the neurobiology of addiction is that repeated cocaine exposure imposes persistent neurochemical and molecular changes, e.g. altered gene expression, in the reward circuitry. The goal of this project is to comprehensively investigate gene expression dysregulation within the mesocorticolimbic reward circuit that may mediate compulsive cocaine taking, using a nonhuman primate model of moderate and excessive cocaine self-administration.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 可卡因滥用和成瘾仍然是全世界的一个主要问题，存在严重的医学和社会经济后果，而治疗这种脑部疾病的有效疗法很少。成瘾神经生物学中的一种流行理论是，重复的可卡因暴露施加了持续的神经化学和分子变化，例如在奖励电路中改变了基因表达。该项目的目的是使用非人类灵长类动物模型中等和过度可卡因自我管理的非人类灵长类动物模型，全面研究中皮层奖励回路中的基因表达失调。