FUNCTION AND PLASTICITY OF PREFRONTAL LOCAL CIRCUITS

额前局部回路的功能和可塑性

• 批准号: 8357975
• 负责人: Wei-Dong Yao
• 金额: $ 1.38万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357975
• 关键词: Disease; Funding; Generations; Grant; Maintenance; Molecular; National Center for Research Resources; Neuronal Dysfunction; Neurons; New England; Pathogenesis; Prefrontal Cortex; Primates; Principal Investigator; Property; Research; Research Infrastructure; Resources; Schizophrenia; Short-Term Memory; Source; Synaptic Transmission; Synaptic plasticity; Time; United States National Institutes of Health; base; cost; neuropsychiatry

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Dysfunction of the neuronal microcircuits in the prefrontal cortex is believed to underline the pathogenesis of some major neuropsychiatric disorders, such as schizophrenia. Generation and maintenance of persistent neuronal activity is one of essential features of these prefrontal circuits underlying many prefrontal functions, including working memory. The aims of this project are to investigate 1) the basic synaptic transmission properties in prefrontal microcircuits, 2) synaptic plasticity, especially spike timing-dependent plasticity (STDP), and its interaction with persistent neuronal activity, 3) the modulatory effects of dopaminergic input and underlying molecular mechanisms.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 据信，前额叶皮层中神经元微电路的功能障碍可强调某些主要神经精神疾病的发病机理，例如精神分裂症。持续性神经元活动的生成和维护是这些前额叶电路的基本特征之一，包括许多前额叶功能，包括工作记忆。该项目的目的是研究1）前额叶微电路中的基本突触传播特性，2）突触可塑性，尤其是峰值定时依赖性可塑性（STDP），及其与持久神经元活性的相互作用，3）多巴胺剂输入和下层分子机制的模块效应。