IMMUNE CORRELATES OF PROTECTION AGAINST SIVE

预防 SIVE 的免疫相关性

• 批准号: 8357927
• 负责人: Susan V. Westmoreland
• 金额: $ 6.84万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357927
• 关键词: AIDS Dementia Complex; AIDS Vaccines; Animals; Antibody Formation; Brain; Development; Funding; Grant; HIV; HIV Infections; HIV encephalitis; Highly Active Antiretroviral Therapy; Immune; Immunity; Lymphoid Tissue; Macaca; Modeling; Morbidity - disease rate; National Center for Research Resources; Neuropathogenesis; New England; Patients; Peripheral; Primates; Principal Investigator; Reporting; Research; Research Infrastructure; Resources; Risk; Role; SIV; SIV encephalitis; Source; United States National Institutes of Health; Viral; Viral Antibodies; base; cell mediated immune response; cost; design; mortality; nervous system disorder; neutralizing antibody; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Despite the widespread use of highly active antiretroviral therapy (HAART), neurological disorders continue to contribute significantly to the morbidity and mortality associated with HIV infection. The immunological correlates of protection against HIV encephalitis (HIVE) have not been identified; however, this information is critical for designing AIDS vaccines that are capable of safely suppressing viral replication in the brain as well as in peripheral lymphoid tissues. Although little is known about the specific effect of antiviral antibodies on the course of HIV neuropathogenesis, recent reports suggest that patients with impaired neutralizing antibody (NAb) responses may be at increased risk for the development of HIV-associated dementia (HAD). In this research program we are using a neurovirulent SIV/macaque model to investigate the role of adaptive host immunity in providing protection against the development of SIV encephalitis (SIVE). The central hypothesis of this project argues that NAb are important for providing collateral protection against the development of SIVE in animals with suboptimal cell-mediated immune responses.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 尽管广泛使用高效抗逆转录病毒疗法（HAART），神经系统疾病仍然对艾滋病毒感染相关的发病率和死亡率产生重大影响。 预防艾滋病毒脑炎 (HIVE) 的免疫学相关性尚未确定；然而，这些信息对于设计能够安全抑制病毒在大脑和外周淋巴组织中复制的艾滋病疫苗至关重要。 尽管人们对抗病毒抗体对 HIV 神经发病过程的具体影响知之甚少，但最近的报告表明，中和抗体 (NAb) 反应受损的患者患 HIV 相关痴呆 (HAD) 的风险可能增加。 在本研究项目中，我们使用神经毒力 SIV/猕猴模型来研究适应性宿主免疫在预防 SIV 脑炎 (SIVE) 发展方面的作用。 该项目的中心假设认为，NAb 对于细胞介导免疫反应欠佳的动物提供针对 SIVE 发展的附带保护非常重要。