GENETICS OF REPRODUCTIVE SENESCENCE

生殖衰老的遗传学

• 批准号: 8357652
• 负责人: MARC TATAR
• 金额: $ 12.16万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357652
• 关键词: Adult; Aging; Animals; Biological Models; Data Analyses; Environment; Funding; Gene Expression; Genetic; Grant; Health; Hemorrhage; Human; Human Genetics; Menstrual cycle; Molecular Profiling; Monitor; National Center for Research Resources; Papio; Pathology; Primates; Principal Investigator; Protocols documentation; Research; Research Infrastructure; Resources; Source; United States National Institutes of Health; Variant; base; cost; genetic pedigree; indexing; reproductive; senescence

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The purpose of this protocol is to establish a model system to study the genetic basis of reproductive aging. The project will study a pedigreed colony of 500 naturally aging adult baboons. The reproductive cycle will be monitored by observation and the animal bled on day 5 and 25 of the menstrual cycle. The data and analysis will identify human genetic regions responsible for variation in reproductive indices of senescence. The colony will provide extensive resources on senescence pathology and gene expression profiles of aging. The combined scale, economy, experimental environment, pedigree and marker set of the aging baboon offers an unprecedented resource to advance our understanding of aging and health in humans.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的首席研究员可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 该协议的目的是建立一个模型系统来研究生殖衰老的遗传基础。该项目将研究由 500 只自然衰老的成年狒狒组成的纯种狒狒群体。通过观察来监测生殖周期，并在月经周期的第5天和第25天对动物进行放血。数据和分析将确定导致衰老生殖指数变化的人类遗传区域。该殖民地将提供有关衰老病理学和衰老基因表达谱的广泛资源。衰老狒狒的综合规模、经济、实验环境、谱系和标记集为增进我们对人类衰老和健康的理解提供了前所未有的资源。