GENETICS OF REPRODUCTIVE SENESCENCE

生殖衰老的遗传学

• 批准号: 8172658
• 负责人: MARC TATAR
• 金额: $ 3.84万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172658
• 关键词: Adult; Aging; Animals; Biological Models; Computer Retrieval of Information on Scientific Projects Database; Data Analyses; Environment; Funding; Gene Expression; Genetic; Grant; Health; Hemorrhage; Human; Human Genetics; Institution; Menstrual cycle; Molecular Profiling; Monitor; Papio; Pathology; Protocols documentation; Research; Research Personnel; Resources; Source; United States National Institutes of Health; Variant; base; genetic pedigree; indexing; reproductive; senescence

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this protocol is to establish a model system to study the genetic basis of reproductive aging. The project will study a pedigreed colony of 500 naturally aging adult baboons. The reproductive cycle will be monitored by observation and the animal bled on day 5 and 25 of the menstrual cycle. The data and analysis will identify human genetic regions responsible for variation in reproductive indices of senescence. The colony will provide extensive resources on senescence pathology and gene expression profiles of aging. The combined scale, economy, experimental environment, pedigree and marker set of the aging baboon offers an unprecedented resource to advance our understanding of aging and health in humans.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该协议的目的是建立一个模型系统来研究生殖衰老的遗传基础。该项目将研究一个有500个自然老化的成人狒狒的建菌群。生殖周期将通过观察结果监测，并在月经周期的第5和25天流血。数据和分析将确定负责衰老生殖指标变化的人类遗传区域。该殖民地将提供有关衰老的衰老病理和基因表达谱的大量资源。老化狒狒的合并规模，经济，实验环境，谱系和标记集提供了前所未有的资源，以促进我们对人类衰老和健康的理解。