Examining the Effect of Behavioral Activation on Substance Use Outcomes

检查行为激活对药物使用结果的影响

• 批准号: 8240704
• 负责人: Jessica F Magidson
• 金额: $ 2.15万
• 依托单位: UNIV OF MARYLAND, COLLEGE PARK
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-15 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8240704
• 关键词: Abnormal coordination; Accounting; Address; Affect; African American; Aftercare; Alcohol or Other Drugs use; Area; Behavioral; Clinical; Complex; Contracts; Control Groups; Counseling; Data; Daughter; Depressed mood; Disease remission; District of Columbia; Dropout; Drops; Drug Rehabilitation Centers; Drug user; Elements; Event; Frequencies; Future; Goals; Health Personnel; Illicit Drugs; Individual; Intervention; Investigation; Life; Link; Low income; Major Depressive Disorder; Manuals; Measures; Mediating; Mediator of activation protein; Mental Depression; Minority; Modeling; Motivation; Nature; Outcome; Patient Self-Report; Patients; Pilot Projects; Population; Population Intervention; Positive Reinforcements; Poverty; Psychological reinforcement; Public Health; Relapse; Residential Treatment; Rewards; Sample Size; Sampling; Staging; Testing; Theoretical model; Time; Treatment outcome; Work; base; career; clinically significant; depressive symptoms; environmental change; ethnic minority population; inner city; meetings; novel; psychosocial; skills; substance abuse treatment; theories; treatment as usual

DESCRIPTION (provided by applicant): Major depressive disorder (MDD) is highly prevalent among substance users, which has significant clinical and public health implications, including poor substance use treatment outcomes. Rates of substance use and depression have been shown to disproportionately affect ethnic minorities in inner-city areas; yet unfortunately, few interventions targeting depression have been developed to meet the specific needs of depressed, minority substance users living in the inner-city. One approach that has been suggested to be useful in this context is behavioral activation (BA), which treats depression by increasing individuals' engagement in pleasant events, and thus increasing positive reinforcement (Jacobson et al., 1996; Lejuez et al., 2001). Daughters and colleagues (2008) have adapted BA to meet the specific needs of inner-city, African American substance users with depression, and in a preliminary pilot study for this treatment [Life Enhancement Treatment for Substance Use (LET'S ACT)], LET'S ACT was associated with a significant reduction in self-reported depressive symptoms and a significant increase in enjoyment and reward value of activities. While preliminary findings for LET'S ACT prove promising, several extensions of the previous study are necessary, including 1) assessment of post-treatment substance use relapse 2) utilization of a contact time-matched control treatment, and 3) the use of a larger sample size to allow for more complex analyses of the mechanisms underlying treatment outcomes. Thus, the current study will address these limitations by comparing LETS ACT to Supportive Counseling (SC) among a sample of 196 low-income substance users with MDD receiving residential substance abuse treatment in inner-city Washington, DC. Depression is prevalent in substance using populations and is associated with poor substance use treatment outcomes, yet few interventions have been developed to treat depression among inner-city, minority illicit drug users. This proposal aims to further develop a behavioral activation treatment for depression specifically for inner-city illicit drug users in residential substance use treatment and examine its effect on substance use treatment dropout and post-treatment relapse.

描述（由申请人提供）：重度抑郁症（MDD）在物质使用者中非常普遍，这具有重大的临床和公共卫生影响，包括不良的物质使用治疗结果。事实证明，药物滥用和抑郁症的发生率对市中心地区的少数族裔影响尤为严重；然而不幸的是，很少有针对抑郁症的干预措施能够满足生活在市中心的抑郁症、少数药物使用者的具体需求。在这种情况下，一种被认为有用的方法是行为激活（BA），它通过增加个体对愉快事件的参与来治疗抑郁症，从而增加积极强化（Jacobson et al., 1996; Lejuez et al., 2001） ）。 Daughters 和同事 (2008) 采用 BA 来满足市中心非裔美国抑郁症物质使用者的特定需求，并在针对这种治疗的初步试点研究中 [物质使用的生命增强治疗 (LET'S ACT)]，LET'S ACT与自我报告的抑郁症状的显着减少以及活动的乐趣和奖励价值的显着增加有关。虽然 LET'S ACT 的初步结果证明是有希望的，但之前研究的一些扩展是必要的，包括 1) 治疗后药物使用复发的评估 2) 使用接触时间匹配的对照治疗，以及 3) 使用更大的样本大小，以便对治疗结果的潜在机制进行更复杂的分析。因此，当前的研究将通过比较 LETS ACT 和支持性咨询 (SC) 来解决这些局限性，该样本是在华盛顿特区内城区接受住宅药物滥用治疗的 196 名患有重度抑郁症 (MDD) 的低收入药物使用者样本中进行的。抑郁症在药物滥用人群中普遍存在，并且与药物滥用治疗结果不佳有关，但目前几乎没有开发出干预措施来治疗市中心少数非法药物使用者的抑郁症。该提案旨在进一步开发一种针对抑郁症的行为激活疗法，专门针对居住在住宅药物使用治疗中的非法药物使用者，并检查其对药物治疗退出和治疗后复发的影响。

项目成果

Rumination Mediates the Relationship Between Distress Tolerance and Depressive Symptoms Among Substance Users.

• DOI: 10.1007/s10608-012-9488-x
• 发表时间: 2013-06-01
• 期刊: Cognitive therapy and research
• 影响因子: 2.8
• 作者: Magidson JF;Listhaus AR;Seitz-Brown CJ;Anderson KE;Lindberg B;Wilson A;Daughters SB
• 通讯作者: Daughters SB